| CODE | CHE3245 | ||||||||||||||||
| TITLE | Separation Techniques and Analytical Chemistry | ||||||||||||||||
| UM LEVEL | 03 - Years 2, 3, 4 in Modular Undergraduate Course | ||||||||||||||||
| MQF LEVEL | 6 | ||||||||||||||||
| ECTS CREDITS | 5 | ||||||||||||||||
| DEPARTMENT | Chemistry | ||||||||||||||||
| DESCRIPTION | 1. Overview of the various types of separation techniques, heterogeneous and homogeneous mixtures, intermolecular interactions, separation choice, recrystallization, sublimation, distillation. 2. Principles of solvent extraction including partition coefficient, distribution ratio (D), pH dependence of D, extraction efficiency, multiple extractions, solvent extraction equilibria, selective extraction of metal ions, solid-phase extraction techniques. 3. Types of chromatography, theory of chromatography including rate theory, solute movement, retention time, adjusted retention time, retention factor, separation factor, plate height, number of theoretical plates, band resolution, adsorption processes and band broadening. 4. Bench-top laboratory chromatographic techniques including thin-layer, column and flash chromatography, solvent choice, gradient eluent, types of absorbents, retention factor, methods of plate development, sample loading, faction size. 5. Gas chromatography (GC) including instrument design, packed columns, types of capillary columns, column characteristics, carrier gases, temperature programming, types of detectors, column efficiency, van Deemter equation, qualitative and quantitative analysis, trouble shooting, internal standard and standard addition analytical methods. 6. High performance liquid chromatography (HPLC) including classes of liquid chromatography (LC), column types, mobile phase choice, HPLC detectors, Huber equation, column efficiency and conditions, qualitative and quantitative analysis, trouble shooting. 7. Ion-exchange chromatography including types of cation and anion exchange resins, resin characteristics, applications of ion-exchange chromatography, regeneration of columns, capillary electrophoresis. 8. Chromatographic-mass spectrometric (MS) techniques including GC-MS and LC-MS, types of mass spectrometry techniques, instrument design, types of mass analysers, sample ionization, electron impact, chemical ionization, electrospray ionization, MALDI, high resolution MS. Study-Unit Aims: - To provide an overview of the separation techniques available in analytical chemistry. - To provide a theoretical overview of the concepts involved in chemical separation science. - To assist students to be able to choose the appropriate technique(s) to solve a chemical separation problem. - To develop analytical problem-solving and critical-thinking skills. Learning Outcomes: 1. Knowledge & Understanding: By the end of the study-unit the student will be able to: - List the various available types of separation techniques and explain fundamental concepts; - Calculate various quantitative parameters in separation science; - Describe the basic design and applications of various chromatographic analytical instrumentation; - Explain the fundamental theory of chromatography separations; - Discuss the importance chemical structure and intermolecular interactions in separation science. 2. Skills: By the end of the study-unit the student will be able to: - Select the correct analytical tool(s) and techniques in order to solve a separation problem, - Perform calculations that allow predictions on how to improve a separation process; - Apply problem-solving and critical thinking skills towards the development of new separation methodologies. Main Text/s and any supplementary readings: Main Text: Quantitative Chemical Analysis, D. C. Harris, 8th ed. 2010. Supplementary Readings: Pharmaceutical Analysis: A Textbook for Pharmacy Students and Pharmaceutical Chemists, D. G. Watson, Harcourts Publishers Limited, 3rd ed. 2012. Chemical Analysis Modern Instrumentation Methods and Techniques, F. Rouessac and A. Rouessac, John Wiley & Sons, 6th ed. 2004. Analytical Chemistry, G. D. Christian, John Wiley & Sons, 6th ed. 2004. Vogel's Textbook of Quantitative Chemical Analysis, J. Mendham, R.C. Denney, J. D. Barnes, M.J.K. Thomas, 6th ed.1999. |
||||||||||||||||
| ADDITIONAL NOTES | Please note that a pass in the Practical component is obligatory for an overall pass mark to be awarded. | ||||||||||||||||
| STUDY-UNIT TYPE | Lecture, Independent Study & Tutorial | ||||||||||||||||
| METHOD OF ASSESSMENT |
|
||||||||||||||||
| LECTURER/S | Noel Aquilina |
||||||||||||||||
|
The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2024/5. It may be subject to change in subsequent years. |
|||||||||||||||||