| CODE | CPH2902 | ||||||||
| TITLE | Pharmacokinetics and Pharmacodynamics 2 | ||||||||
| UM LEVEL | 02 - Years 2, 3 in Modular Undergraduate Course | ||||||||
| MQF LEVEL | 5 | ||||||||
| ECTS CREDITS | 4 | ||||||||
| DEPARTMENT | Clinical Pharmacology and Therapeutics | ||||||||
| DESCRIPTION | This study-unit will provide further understanding of the principles of pharmacokinetics and biopharmaceutics including the used of software-based pharmacokinetics and pharmacodynamic software modelling. It will delve into how these pharmacokinetic principles can be applied to achieve successful drug therapy in the clinical and population setting. The applications of principles and equations are illustrated with related problem sets and problem solving exercises. There be further understanding of the use of graphical, simulation and physiological profiles (sketches of relationships among pharmacokinetic and pharmacodyanmic variables and parameters) This study-unit will also delve into metabolite and urine pharmacokinetics and pharmacokinetic data fitting. Study-unit Aims: - Provide an overview of the impact of interpatient and intrapatient variability in pharmacokinetics and pharmacodynamic data; - Appreciate methodologies used to model linear, nonlinear and toxicokinetics; - Review limitations of pharmacokinetics and pharmacodynamic modelling; - Give information on the role of population pharmacokinetics; - Assess the role of differing pharmacokinetics and pharmacodynamic software; - Assess the mechanisms of pharmacokinetics and pharmacodynamics in understanding drug drug interactions; - Provide an understanding of role of therapeutic drug monitoring in the interpretation of pharmacokinetics and pharmacodynamic data; - Appreciate metabolite and urine pharmacokinetics and data fitting. Learning Outcomes 1. Knowledge & Understanding By the end of the study-unit the student will be able to: - Evaluate the various diagnostic tools used to study the impact of interpatient and intrapatient variability in pharmacokinetics and pharmacodynamic data; - Outline the role of population pharmacokinetics in linear, nonlinear and toxicokinetics; - Appreciate mechanisms of pharmacokinetics and pharmacodynamics in understanding drug drug interactions; - Evaluate the use of therapeutic drug monitoring in the interpretation of pharmacokinetics and pharmacodynamic data; - Outline metabolite and urine pharmacokinetics and data fitting; - Evaluate the role of differing pharmacokinetics and pharmacodynamic software. 2. Skills By the end of the study-unit the student will be able to: - Plan diagnostic tools used to study the impact of interpatient and intrapatient variability in pharmacokinetics and pharmacodynamic data; - Examine mechanisms of pharmacokinetics and pharmacodynamics in understanding drug drug interactions; - Explain how therapeutic drug monitoring can be used in the interpretation of pharmacokinetics and pharmacodynamic data; - Interpret the role of pharmacokinetics and pharmacodynamic software in clinical scenarios; - Predict the limitations of pharmacokinetics and pharmacodynamic modelling; - Explain metabolite and urine pharmacokinetics and data fitting and the role of population pharmacokinetics. Main Text/s and any supplementary readings: Main text: - Ritter JM, Flower RJ, Henderson G, Loke YK, MacEwan D, Rang HP. Rang & Dale's Pharmacology. 9th Ed. 2019. Elsevier. - Derendorf H, Schmidt S Ph.D. Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications. 5th Ed. 2019. Lippincott Williams and Wilkins. - British National Formulary. Pharmaceutical Press. (issued bi-annually). Supplementary readings: - Tozer TN. Essentials of Pharmacokinetics and Pharmacodynamics. 2nd Ed. 2015. Lippincott Williams & Wilkins. - Trevor AJ, Katzung BG. Basic and Clinical Pharmacology. 15th Ed. 2021. Mcgraw Hill Medical. - Brunton L, Knollmann B, Hilal-Dandan R.Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Ed. 2017. McGraw-Hill Education. Revision aids: - Karen Whalen. Lippincott Illustrated Reviews: Pharmacology. 2018. Lippincott Williams and Wilkins. Journals: - Molecular pharmacology. Published by the American Society for Pharmacology and Experimental Therapeutics. - British Journal of Pharmacology. Published by the British Pharmacological Society. - British Journal of Clinical Pharmacology. Published by the British Pharmacological Society. |
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| STUDY-UNIT TYPE | Lecture and Independent Study | ||||||||
| METHOD OF ASSESSMENT |
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| LECTURER/S | Maria Xiberras Kevin Abela Janet Mifsud (Co-ord.) Patricia Vella Bonanno |
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The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2024/5. It may be subject to change in subsequent years. |
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