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https://www.um.edu.mt/library/oar/handle/123456789/13089
Title: | Species variations in drug metabolism : investigations on the liver microsomal hydroxylation of tryptamine and related compounds |
Authors: | Jaccarini, Anthony P. |
Keywords: | Drugs -- Metabolism -- Research Hydroxylation Tryptamine |
Issue Date: | 1967 |
Publisher: | The St. Luke`s Hospital Gazette |
Citation: | Jaccarini, A. (1967).Species variations in drug metabolism: investigations on the liver microsomal hydroxylation of tryptamine and related compounds. The St. Luke`s Hospital Gazette, 2(2), 121-124. |
Abstract: | Various tryptamines and indoles were incubated with microsomal preparations obtained from different animal species. The variation of liver microsomal indole 6-hydroxylase activity in different animals exemplifies the species dependence of the drug metabolising enzymes. Age and sex are also factors which have to be considered in studies on drug hydroxylations. Since these species variations render the extrapolation of data from animal to man difficult, a partial but direct approach would involve the use of human liver tissue for the investigations ‘in vitro’ which are necessary in the preliminary stages of the development of new drugs. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/13089 |
Appears in Collections: | TSLHG, Volume 2, Issue 2 TSLHG, Volume 2, Issue 2 |
Files in This Item:
File | Description | Size | Format | |
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Specific Variations in Drug Metabolism-Investigations on the Liver Microsomal Hydroxylation of Tryptamine and Related Compounds.pdf | Published for the Consultant Staff Committee, St. Luke`s Hospital, Malta and the Medical and Dental Surgery Faculties of the Royal University of Malta. | 259.17 kB | Adobe PDF | View/Open |
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