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Title: | Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration : a neurochemical study |
Authors: | Di Matteo, Vincenzo Pierucci, Massimo Benigno, Arcangelo Crescimanno, Giuseppe Esposito, Ennio Di Giovanni, Giuseppe |
Keywords: | Parkinson's disease Nitric oxide Corpus striatum Substantia nigra Dopamine Oxidopamine |
Issue Date: | 2009 |
Publisher: | Wiley-Blackwell Publishing, Inc. |
Citation: | Di Matteo, V., Pierucci, M., Benigno, A., Crescimanno, G., Esposito, E., & Di Giovanni, G. (2009). Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration : a neurochemical study. Annals of the New York Academy of Sciences, 1155, 309-315. |
Abstract: | The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n= 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, n= 5), an NO donor, significantly worsened the neurodegeneration (n= 5) and completely counteracted the neuroprotective effect of 7-NI (n= 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a protective benefit for inhibitors of NOS in the treatment of PD. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/22767 |
Appears in Collections: | Scholarly Works - FacM&SPB |
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Matteo_et_al-2009-Annals_of_the_New_York_Academy_of_Sciences.pdf Restricted Access | 138.44 kB | Adobe PDF | View/Open Request a copy |
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