Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/25650
Title: | The role of kisspeptin signalling in the hypothalamic-pituitary-gonadal axis |
Authors: | Cardona Attard, Carol |
Keywords: | Kisspeptin neurons Gonadotropin Luteinizing hormone releasing hormone Hypogonadism -- Treatment |
Issue Date: | 2017 |
Publisher: | University of Malta. Medical School |
Citation: | Cardona Attard, C. (2017). The role of kisspeptin signalling in the hypothalamic-pituitary-gonadal axis. Malta Medical Journal, 29(3), 30-36. |
Abstract: | Kisspeptin is a hypothalamic peptide hormone, which plays a crucial role in puberty and fertility control by stimulating the release of gonadotrophin-releasing hormone, which in turn stimulates the release of luteinizing hormone and follicle stimulating hormone. It also interacts with neuropeptides neurokinin B and dynorphin A, and is under negative and positive feedback influences relayed by gonadal sex steroids. Loss of kisspeptin signalling results in hypogonadotrophic hypogonadism and impaired puberty. Kisspeptin expression and secretion is also affected by metabolic status and stress. Several studies have indicated a potential role for kisspeptin in the treatment of disorders causing hypogonadotrophic hypogonadism. This review aims to summarize the importance of kisspeptin and its role in the hypothalamic- pituitary-gonadal axis. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/25650 |
Appears in Collections: | MMJ, Volume 29, Issue 3 MMJ, Volume 29, Issue 3 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
MMJ 29(3) - A4.pdf | 927.23 kB | Adobe PDF | View/Open |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.