The temporal progression and natural history of intermittent claudication : a review of current evidence

Abstract

Background: Intermittent claudication (IC) is the most common symptom of peripheral arterial disease. Due to the benign prognosis in the majority of patients, treatment is generally aimed at risk factor control. However, approximately 15% of patients with IC deteriorate to critical limb ischaemia (CLI), with increased risk of adverse cardiovascular events, amputation and death. Understanding the natural history and the temporal progression of IC, would help in identifying those with increased likelihood of developing CLI. This information is crucial in the clinical decision whether to offer surgical revascularisation. A structured review of the current knowledge related to the temporal progression of symptomatic PAD and the prognosis of IC was conducted. [Excerpt]