Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/101650
Title: Drug utilization 75% (DU75%) in 17 European hospitals (2000 - 2005) : results from the ESAC-2 hospital care sub project
Authors: Zarb, Peter
Ansari, Faranak
Muller, Arno
Vankerckhoven, Venessa
Davey, Peter G.
Goossens, Herman
Keywords: Tuberculosis -- Case studies
Anti-infective agents
Drug utilization
Amoxicillin
Enzyme inhibitors -- Therapeutic use
Benzylpiperazine
Antibiotics
Rifampin
Issue Date: 2011
Publisher: Bentham Science Publishers Ltd.
Citation: Zarb, P., Ansari, F., Muller, A., Vankerckhoven, V., G Davey, P., & Goossens, H. (2011). Drug utilization 75%(DU75%) in 17 European hospitals (2000-2005): results from the ESAC-2 Hospital Care Sub Project. Current clinical pharmacology, 6(1), 62-70.
Abstract: The study aimed to assess 75% of drug utilization (DU75%) in participating hospitals and identify quality indicators which should be used to monitor performance within the hospitals. In the European Surveillance of Antimicrobial Consumption (ESAC; http://www.esac.ua.ac.be) project anatomic therapeutic chemical (ATC), defined daily dose (DDD) and route of administration (RoA) were used for drug categorization. Data were collected for: antibacterials for systemic use; intestinal antibiotics; rifampicin; and nitroimidazole derivatives. Each hospitals annual data were analyzed separately (hospital-year) adding up to a total of 97 hospital-year data-sets. The drug most persistently present within DU75% was ciprofloxacin (84/97 hospital-years). Co-amoxiclav was the drug which most frequently ranked first (28 times). The number of drugs constituting the DU75% by substance ranged from 7-15 (median 12) and 8- 19 (median 15) by RoA which identified oral amoxicillin most frequently ranking first (17 times). In many hospitals the oral route accounted for most of the DU75%. Therefore, the extent of oral use was identified as a quality indicator which could be monitored using DU75% methodology. Since substantial variation both in extent and distribution of antibiotic use was observed, DU75% methodology is best adapted for intra-hospital consumption trend analyses or for hospitals with comparable characteristics and formularies. The number of drugs within DU75% was identified as another quality indicator. Thus, aspiring to decrease the consumption of overused drug classes should be set by the hospitals as a quality indicator on prescribing patterns.
URI: https://www.um.edu.mt/library/oar/handle/123456789/101650
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