Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/102857
Title: | Sleep-disordered breathing is associated with reduced mandibular cortical width in children |
Authors: | Eimar, H. Al-Saleh, M. A. Q. Cortes, Arthur R. G. Gozal, D. Graf, D. Flores-Mir, C. |
Keywords: | Sleep apnea syndromes -- Diagnosis Mandible Dentistry Linear topological spaces Tomography -- Diagnostic use |
Issue Date: | 2019 |
Publisher: | International & American Associations for Dental Research |
Citation: | Eimar, H., Al-Saleh, M.A.Q., Cortes, A. R. G., Gozal, D, Graf, D., Flores-Mir, C. (2019). Sleep-Disordered Breathing Is Associated with Reduced Mandibular Cortical Width in Children. JDR Clinical & Translational Research, 4(1), 58-67. |
Abstract: | Introduction:Evidence from the adult population suggests that sleep-disordered breathing (SDB) (i.e., obstructive sleep apnea [OSA]) is negatively associated with bone mineral density. Whether a similar association exists in children with SDB has not been investigated. Using the mandibular cortical width (MCW) as a proxy for skeletal bone density, we investigated if children at risk of SDB or diagnosed with OSA have a reduced mandibular cortical width compared to children without SDB. Methods:Two retrospective cross-sectional studies were performed. The first study included comparison of MCW between 24 children with polysomnographically (PSG) diagnosed OSA and 72 age- and sex-matched control children. The second study included a cohort of children in which SDB was suggested by the Pediatric Sleep Questionnaire (PSQ) (n = 101). MCW was measured from panoramic radiographs. Results:Multiple-predictors regression analysis from the first study indicated that in children with a severe form of SDB, as induced by OSA severity, there was a negative association with MCW (β = –0.290, P = 0.049). Moreover, PSG-diagnosed OSA children had thinner MCW (2.9. ± 0.6mm) compared to healthy children (3.5 ± 0.6 mm; P = 0.002). These findings were further supported by the second study illustrating that PSQ total scores were negatively associated with MCW (β = –0.391, P < 0.001). Conclusions:Findings suggest that children at risk for or diagnosed with SDB exhibit reduced mandibular cortical width that purportedly may reflect alterations in bone homeostasis. Knowledge Transfer Statement:We report that sleep-disordered breathing (including its severe form, obstructive sleep apnea) in children is associated with reduced mandibular cortical width. This association might be a direct consequence of reduced bone health to sleep-disordered breathing or a reflection that reduced bone formation underlies the development of sleep-disordered breathing. Our findings suggest that mandibular cortical width can be used as an adjunct diagnostic parameter for the diagnosis of sleep-disordered breathing. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/102857 |
Appears in Collections: | Scholarly Works - FacDenDS |
Files in This Item:
File | Description | Size | Format | |
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Sleep_disordered_breathing_is_associated_with_reduced_mandibular_cortical_width_in_children.pdf | 182.49 kB | Adobe PDF | View/Open |
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