Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/102961
Title: | Two-dimensional magnesium phosphate nanosheets form highly thixotropic gels that up-regulate bone formation |
Authors: | Laurenti, Marco Al Subaie, Ahmed Abdallah, Mohamed-Nur Cortes, Arthur R. G. Ackerman, Jerome L. Vali, Hojatollah Basu, Kaustuv Zhang, Yu Ling Murshed, Monzur Strandman, Satu Zhu, Julian Makhoul, Nicholas Barralet, Jake E. Tamimi, Faleh |
Keywords: | Bone regeneration Nanostructured materials -- Therapeutic use Tissue engineering Magnesium phosphate Bone substitutes Two-dimensional materials |
Issue Date: | 2016 |
Publisher: | American Chemical Society |
Citation: | Laurenti, M., Al Subaie, A., Abdallah, M. N., Cortes, A. R. G., Ackerman, J. L., Vali, H.,...Tamimi, F. (2016). Two-dimensional magnesium phosphate nanosheets form highly thixotropic gels that up-regulate bone formation. Nano Letters, 16(8), 4779-4787. |
Abstract: | Hydrogels composed of two-dimensional (2D) nanomaterials have become an important alternative to replace traditional inorganic scaffolds for tissue engineering. Here, we describe a novel nanocrystalline material with 2D morphology that was synthesized by tuning the crystallization of the sodium-magnesium-phosphate system. We discovered that the sodium ion can regulate the precipitation of magnesium phosphate by interacting with the crystal’s surface causing a preferential crystal growth that results in 2D morphology. The 2D nanomaterial gave rise to a physical hydrogel that presented extreme thixotropy, injectability, biocompatibility, bioresorption, and long-term stability. The nanocrystalline material was characterized in vitro and in vivo and we discovered that it presented unique biological properties. Magnesium phosphate nanosheets accelerated bone healing and osseointegration by enhancing collagen formation, osteoblasts differentiation, and osteoclasts proliferation through up-regulation of COL1A1, RunX2, ALP, OCN, and OPN. In summary, the 2D magnesium phosphate nanosheets could bring a paradigm shift in the field of minimally invasive orthopedic and craniofacial interventions because it is the only material available that can be injected through high gauge needles into bone defects in order to accelerate bone healing and osseointegration. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/102961 |
Appears in Collections: | Scholarly Works - FacDenDS |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Two dimensional magnesium phosphate nanosheets form highly thixotropic gels that up regulate bone formation 2016.pdf Restricted Access | 6.3 MB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.