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Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/103380
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dc.contributor.authorGatt, Alexander-
dc.contributor.authorvan Veen, Joost J.-
dc.contributor.authorCooper, Peter-
dc.contributor.authorKitchen, Steve-
dc.contributor.authorMakris, Michael-
dc.date.accessioned2022-11-04T06:56:33Z-
dc.date.available2022-11-04T06:56:33Z-
dc.date.issued2007-
dc.identifier.citationGatt, A., van Veen, J. J., Cooper, P., Kitchen, S., & Makris, M. (2007). Protein C deficiency screening using a thrombin generation assay–an upgrade. Thrombosis and Haemostasis, 98(09), 691-692.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/103380-
dc.description.abstractWe read with interest the letter by Hézard et al. regarding a modified thrombin generation (TG) assay using Protac® as a screening tool for protein C (PC) deficiency. We have developed a similar modification in order to make the TG- assay more sensitive to changes in the protein C pathway. We tested 122 patients (32 controls, 38 heterozygous for factor V Leiden, 34 family members of patients with an inherited thrombophilia with normal thrombophilia screens, 8 with PC deficiency and 10 with protein S deficiency) enrolled in a previous thrombophilia study. Although our assay is similar to the assay described by Hézard et al., we feel that there are important differences that impact on the reproducibility and accuracy of this test.en_GB
dc.language.isoenen_GB
dc.publisherGeorg Thieme Verlagen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectProtein C deficiency -- Pathophysiologyen_GB
dc.subjectThrombin -- Physiological effecten_GB
dc.titleProtein C deficiency screening using a thrombin generation assay – an upgradeen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1160/TH07–04–0314-
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