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DC Field | Value | Language |
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dc.contributor.author | Tsochatzis, E. A. | - |
dc.contributor.author | Senzolo, M. | - |
dc.contributor.author | Germani, G. | - |
dc.contributor.author | Gatt, Alexander | - |
dc.contributor.author | Burroughs, A. K. | - |
dc.date.accessioned | 2022-11-04T08:14:54Z | - |
dc.date.available | 2022-11-04T08:14:54Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Tsochatzis, E. A., Senzolo, M., Germani, G., Gatt, A., & Burroughs, A. K. (2010). Systematic review: portal vein thrombosis in cirrhosis. Alimentary Pharmacology & Therapeutics, 31(3), 366-374. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/103392 | - |
dc.description.abstract | Background: As current imaging techniques in cirrhosis allow detection of asymptomatic portal vein thrombosis during routine ultrasonography, more patients with cirrhosis are diagnosed with portal vein thrombosis. Although a consensus on noncirrhotic extra-hepatic portal vein thrombosis has been published, no such consensus exists for portal vein thrombosis with cirrhosis. Aim: To perform a systematic review of nonmalignant portal vein thrombosis in cirrhosis in terms of prevalence, pathogenesis, diagnosis, clinical course and management. Methods: Studies were identified by a search strategy using MEDLINE and EMBASE. Results: Portal vein thrombosis is encountered in 10–25% of cirrhotics. In terms of pathophysiology, cirrhosis is no longer considered a hypocoagulable state; rather than a bleeding risk in cirrhosis, various clinical studies support a thrombotic potential. Clinical findings of portal vein thrombosis in cirrhosis vary from asymptomatic disease to a life-threatening condition at first presentation. Optimal management of portal vein thrombosis in cirrhosis is currently not addressed in any consensus publication. Treatment strategies most often include the use of anticoagulation, while thrombectomy and transjugular intrahepatic portosystemic shunts are considered second-line options. Conclusions: Portal vein thrombosis in cirrhosis has many unresolved issues, which are often the critical problems clinicians encounter in their everyday practice. We propose a possible research agenda to address these unresolved issues. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Wiley-Blackwell Publishing Ltd. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Liver -- Cirrhosis | en_GB |
dc.subject | Liver -- Diseases -- Etiology | en_GB |
dc.subject | Liver -- Imaging | en_GB |
dc.subject | Thrombophlebitis -- Diagnosis | en_GB |
dc.subject | Thrombosis -- Diagnosis | en_GB |
dc.title | Systematic review : portal vein thrombosis in cirrhosis | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1111/j.1365-2036.2009.04182.x | - |
dc.publication.title | Alimentary Pharmacology & Therapeutics | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPat |
Files in This Item:
File | Description | Size | Format | |
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Systematic review portal vein thrombosis in cirrhosis 2010.pdf Restricted Access | 90.08 kB | Adobe PDF | View/Open Request a copy |
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