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DC Field | Value | Language |
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dc.contributor.author | Agarwal, Banwari | - |
dc.contributor.author | Wright, Gavin | - |
dc.contributor.author | Gatt, Alexander | - |
dc.contributor.author | Riddell, Anne | - |
dc.contributor.author | Vemala, Vishwaraj | - |
dc.contributor.author | Mallett, Susan | - |
dc.contributor.author | Chowdary, Pratima | - |
dc.contributor.author | Davenport, Andrew | - |
dc.contributor.author | Jalan, Rajiv | - |
dc.contributor.author | Burroughs, Andrew | - |
dc.date.accessioned | 2022-11-04T08:24:47Z | - |
dc.date.available | 2022-11-04T08:24:47Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Agarwal, B., Wright, G., Gatt, A., Riddell, A., Vemala, V., Mallett, S.,...Burroughs, A. (2012). Evaluation of coagulation abnormalities in acute liver failure. Journal of Hepatology, 57(4), 780-786. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/103396 | - |
dc.description.abstract | Background & Aims: In acute liver failure (ALF), prothrombin time (PT) and its derivative prothrombin time ratio (PTR) are elevated, and are considered predictors of increased bleeding risk. We aimed at determining whether increased PT/PTR reflects the haemostatic potential and bleeding risk in ALF patients. | en_GB |
dc.description.abstract | Methods: Twenty consecutive ALF patients were recruited. Samples were analysed on admission for standard laboratory clotting tests (e.g. PT), thromboelastography (TEG), individual pro and anticoagulant factors and thrombin generation (TG) kinetics with and without Protac , a snake venom protein C activator, and microparticle assay. TG was also measured in 20 age and sex matched healthy volunteers. | en_GB |
dc.description.abstract | Results: PT was significantly raised (50.7 s ± 7.2, p = 0.0001) but did not correlate with TEG parameters. TEG tracings were consistent with a hypocoagulable state in 20%, normal in 45%, and hypercoagulable in 35% of the patients. There was a concomitant and proportional reduction in plasma levels of both procoagulants and natural anticoagulant proteins, in conjunction with a significant elevation in plasma levels of factors-VIII (FVIII) and Von Willebrand factor, and microparticles, culminating in an overall efficient, albeit reduced, thrombin generation capacity in comparison with healthy individuals. A heparin-like effect (HLE) was also noted in most patients. No significant clinical bleeding complications occurred and no blood transfusions were required. | en_GB |
dc.description.abstract | Conclusions: In ALF, despite grossly deranged PT in all patients, estimation of bleeding risk suggests that the coagulation disturbance in ALF patients is complex and heterogeneous for which an individualised approach is required. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Liver -- Failure -- Complications | en_GB |
dc.subject | Liver -- Diseases -- Case studies | en_GB |
dc.subject | Liver failure, acute | en_GB |
dc.subject | Blood coagulation factors | en_GB |
dc.subject | Prothrombin time | en_GB |
dc.title | Evaluation of coagulation abnormalities in acute liver failure | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.jhep.2012.06.020 | - |
dc.publication.title | Journal of Hepatology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPat |
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Evaluation of coagulation abnormalities in acute liver failure 2012.pdf Restricted Access | 610.72 kB | Adobe PDF | View/Open Request a copy |
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