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DC Field | Value | Language |
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dc.contributor.author | Gatt, Alexander | - |
dc.contributor.author | van Veen, J. J. | - |
dc.contributor.author | Bowyer, A. | - |
dc.contributor.author | Woolley, A. M. | - |
dc.contributor.author | Cooper, P. | - |
dc.contributor.author | Kitchen, S. | - |
dc.contributor.author | Makris, M. | - |
dc.date.accessioned | 2022-11-04T08:30:42Z | - |
dc.date.available | 2022-11-04T08:30:42Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Gatt, A., Van Veen, J. J., Bowyer, A., Woolley, A. M., Cooper, P., Kitchen, S., & Makris, M. (2008). Wide variation in thrombin generation in patients with atrial fibrillation and therapeutic International Normalized Ratio is not due to inflammation. British Journal of Haematology, 142(6), 946-952. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/103398 | - |
dc.description.abstract | Atrial fibrillation (AF) is a common cardiac arrhythmia with a 5–20% annual risk of stroke. Warfarin reduces this risk by at least 60%. Despite adequate anticoagulation within the target International Normalized Ratio (INR) range of 2Æ0–3Æ0, some patients still experience thrombotic and bleeding events. It is now possible to assess the intensity of anticoagulation with automated thrombin generation (TG) tests, such as the calibrated automated thrombogram (CAT). These tests were compared and an inverse relationship was found between the INR and CAT in 143 elderly AF patients. There was equally good correlation between the concentration of factors II, VII, IX and X and the INR and TG parameters. The peak thrombin was most strongly associated with the concentration of prothrombin fragment 1 + 2 in plasma. There was wide variability in TG parameters in patients with identical INR values, sometimes up to a fourfold difference. This TG variability in individuals with the same INR is not due to inflammation, at least when the latter is measured as the concentration of factor VIII coagulant activity, von Willebrand factor antigen, high sensitivity C-reactive protein and fibrinogen. It was concluded that, although the TG and INR were closely correlated there was wide variability in peak thrombin and endogenous thrombin potential in patients within the INR therapeutic range, the cause of which remains unclear. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Wiley-Blackwell Publishing, Inc. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Atrial fibrillation -- Risk factors | en_GB |
dc.subject | Thrombin -- Physiological effect | en_GB |
dc.subject | Blood coagulation factor VIII | en_GB |
dc.subject | Blood coagulation tests | en_GB |
dc.subject | International Normalized Ratio | en_GB |
dc.title | Wide variation in thrombin generation in patients with atrial fibrillation and therapeutic International Normalized Ratio is not due to inflammation | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1111/j.1365-2141.2008.07279.x | - |
dc.publication.title | British Journal of Haematology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPat |
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Wide variation in thrombin generation in patients with atrial fibrillation and therapeutic International Normalized Ratio is not due to inflammation 2008.pdf Restricted Access | 165.03 kB | Adobe PDF | View/Open Request a copy |
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