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DC Field | Value | Language |
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dc.contributor.author | Rizzo, Kirsty | - |
dc.contributor.author | Zammit, Daniel | - |
dc.contributor.author | Gatt, Peter | - |
dc.contributor.author | Grima, Charlie | - |
dc.contributor.author | Borg Inguanez, Monique | - |
dc.contributor.author | Gerada, Jurgen | - |
dc.contributor.author | Ellul, Pierre | - |
dc.contributor.author | Vassallo, Mario | - |
dc.contributor.author | Azzopardi, Neville | - |
dc.contributor.author | Pocock, James | - |
dc.contributor.author | Gatt, Alexander | - |
dc.date.accessioned | 2022-11-07T06:41:49Z | - |
dc.date.available | 2022-11-07T06:41:49Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Rizzo, K., Vella, K., Zammit, D., Gatt, P., Grima, C., Inguanez, M. B.,...Gatt, A. (2019). Fibrinogen measurement in liver disease: validation of the functional fibrinogen thromboelastography assay and a novel mathematical predictive model. Blood Transfusion, 17(3), 237-246. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/103419 | - |
dc.description.abstract | Background. Fibrinogen is produced in the liver and tends to be reduced in liver cirrhosis. Quantitative and qualitative tests exist to measure fibrinogen. We aimed to validate the functional fibrinogen thromboelastography assay (FF-TEG) and propose a new model to estimate fibrinogen levels via the Clauss method (Clauss) using data from a prothrombin time-derived fibrinogen assay (PT-Fg) in patients with liver cirrhosis. Materials and methods. Clauss, PT-Fg, fibrinogen antigen (Fib-Ag) and FF-TEG were studied in 55 patients with liver cirrhosis (26 with Child-Turcotte-Pugh [CTP]-A disease, 14 with CTP-B and 15 CTP-C) and 20 healthy individuals. Results. The results of all four assays correlated strongly with each other, but gave significantly different mean levels in all cohorts. PT-Fg gave the highest levels whereas the Clauss gave the lowest levels. The FF-TEG performed well with results which were in between the Clauss and the PT-Fg. Significant differences were only observed between CTP-A and CTP-C for the Clauss, PT-Fg and Fib-Ag but not functional fibrinogen level. We devised a simple linear regression model in order to estimate Clauss from the PT-Fg. Discussion. The results of the FF-TEG correlate well with those of routine fibrinogen assays in patients with liver cirrhosis. However, the FF-TEG assay does not discriminate between early and late stages of disease, pointing to a preserved fibrin clot strength in cirrhosis. Through linear regression models, fibrinogen levels can be accurately estimated using the Clauss method based on fibrinogen levels obtained in the cheaper PT-Fg. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | SIMTIPRO Srl | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Fibrinogen | en_GB |
dc.subject | Fibrinogen polymorphisms | en_GB |
dc.subject | Liver -- Diseases -- Malta -- Case studies | en_GB |
dc.subject | Liver -- Cirrhosis -- Diagnosis | en_GB |
dc.title | Fibrinogen measurement in liver disease : validation of the functional fibrinogen thromboelastography assay and a novel mathematical predictive model | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.2450/2018.0105-18 | - |
dc.publication.title | Blood Transfusion | en_GB |
dc.contributor.author2 | Vella, Kevin | - |
Appears in Collections: | Scholarly Works - FacM&SPat |
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