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DC Field | Value | Language |
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dc.contributor.author | Van Veen, Joost J. | - |
dc.contributor.author | Gatt, Alexander | - |
dc.contributor.author | Bowyer, Annette E. | - |
dc.contributor.author | Cooper, Peter C. | - |
dc.contributor.author | Kitchen, Steve | - |
dc.contributor.author | Makris, Mike | - |
dc.date.accessioned | 2022-11-07T14:46:35Z | - |
dc.date.available | 2022-11-07T14:46:35Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Van Veen, J. J., Gatt, A., Bowyer, A. E., Cooper, P. C., Kitchen, S., & Makris, M. (2009). Calibrated automated thrombin generation and modified thromboelastometry in haemophilia A. Thrombosis Research, 123(6), 895-901. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/103452 | - |
dc.description.abstract | Global coagulation tests may have a better relation with phenotype in haemophilia than traditional coagulation tests. These include the Calibrated Automated Thrombin generation assay (CAT) and modified thromboelastometry using low tissue factor triggering. Both have shown marked variability in thrombin generation and clot formation profiles respectively despite similar FVIII:C levels and have been suggested as means to monitor treatment. Data with modified thromboelastometry are largely limited to severe and moderate haemophiliacs. CAT measurements in haemophilia are generally performed at low TF concentrations (1 pM) because of a higher sensitivity for the intrinsic pathway at this concentration but is also sensitive for FVIII at higher concentrations (5 pM) and this has the advantage that inhibition of contact factor activation can be avoided. No formal comparison of both TF concentrations has been reported and the data on modified thromboelastometry in mild haemophilia are limited. Methods: In this study we compared thrombin generation at 1 and 5 pM in 57 haemophilia patients without exposure to treatment and 41 patients after treatment. We also assessed the sensitivity of thromboelastometry for haemophilia A in 29 patients. Results and conclusion: We found that CAT discriminates well between normal individuals and haemophilia patients; also FVIII:C correlates well with the ETP/peak. We found no clear advantages of measurements at 1 compared to 5 pM but found increased variation over time at 1 pM. The sensitivity of modified thromboelastometry for haemophilia A was less than CATwith abnormalmeasurements largely limited to severe and moderate patients. Larger studies correlating both methods with clinical outcome are required. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Thrombelastography | en_GB |
dc.subject | Hemophilia -- Case studies | en_GB |
dc.subject | Blood coagulation tests | en_GB |
dc.subject | Thrombin -- Analysis | en_GB |
dc.title | Calibrated automated thrombin generation and modified thromboelastometry in haemophilia A | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.thromres.2008.09.011 | - |
dc.publication.title | Thrombosis Research | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPat |
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Calibrated automated thrombin generation and modified thromboelastometry in haemophilia A 2009.pdf Restricted Access | 647.47 kB | Adobe PDF | View/Open Request a copy |
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