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DC Field | Value | Language |
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dc.contributor.author | Chowdary, Pratima | - |
dc.contributor.author | Adamidou, Despoina | - |
dc.contributor.author | Riddell, Anne | - |
dc.contributor.author | Aghighi, Saman | - |
dc.contributor.author | Griffioen, Anja | - |
dc.contributor.author | Priest, Paul | - |
dc.contributor.author | Moghadam, Lida | - |
dc.contributor.author | Kelaher, Nicholas | - |
dc.contributor.author | Huq, Farah Y. | - |
dc.contributor.author | Kadir, Rezan A. | - |
dc.contributor.author | Tuddenham, Edward G. | - |
dc.contributor.author | Gatt, Alexander | - |
dc.date.accessioned | 2022-11-10T14:01:41Z | - |
dc.date.available | 2022-11-10T14:01:41Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Chowdary, P., Adamidou, D., Riddell, A., Aghighi, S., Griffioen, A., Priest, P., ... & Gatt, A. (2015). Thrombin generation assay identifies individual variability in responses to low molecular weight heparin in pregnancy : implications for anticoagulant monitoring. British journal of Haematology, 168(5), 719-727. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/103556 | - |
dc.description.abstract | Low molecular weight heparin (LMWH) given to inhibit coagulation and reduce the risk of thrombosis, is typically monitored by anti-Xa assay. However, anti-Xa levels may not necessarily provide an accurate measure of coagulation inhibition. Moreover, pregnancy is associated with hypercoagulability, which may compromise the efficacy of LMWH. We looked at the association between anti-Xa levels and parameters of thrombin generation assay [TGA; area under the curve (AUC), peak height (PH) and time to peak (ttP)] using samples from 41 pregnant women receiving LMWH and 40 normal pregnant women controls. TGA results confirmed the physiological hypercoagulability of normal pregnancy (mean normalised values: AUC 119%; PH 157%; ttP 72%). Although anti-Xa measures correlated with all three TGA parameters, this group correlation masked significant inter-individual variability, demonstrated by the R2 value or coefficient of determination. Anti-Xa levels contributed to 74% of variation in AUC values, 63% of variation in PH values and only 53% of variation in ttP values. The remainder reflects the contribution of patients’ intrinsic coagulation status. Hence, some patients with ‘safe’ anti-Xa levels may potentially be under-anticoagulated, particularly in pregnancy. Measuring coagulability directly with TGA may lower the risk of adverse events due to under-anticoagulation in selected patients. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | John Wiley & Sons Ltd | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Pregnancy | en_GB |
dc.subject | Thrombin | en_GB |
dc.subject | Heart valves | en_GB |
dc.subject | Heparin | en_GB |
dc.title | Thrombin generation assay identifies individual variability in responses to low molecular weight heparin in pregnancy : implications for anticoagulant monitoring | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1111/bjh.13193 | - |
dc.publication.title | British Journal of Haematology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPat |
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