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Title: | Abstract B22 : identification of novel drug combinations to target molecular pathways involved in breast cancer |
Other Titles: | Identification of novel drug combinations to target molecular pathways involved in breast cancer |
Authors: | Petroni, Vanessa Camilleri Podesta, Marie Therese Fenech, Anthony George Grech, Godfrey |
Keywords: | Breast -- Cancer -- Treatment Statins (Cardiovascular agents) Hydroxymethylglutaryl coenzyme A reductases mTOR associated protein, LST8 homolog Rapamycin |
Issue Date: | 2015 |
Publisher: | American Association for Cancer Research |
Citation: | Petroni, V., Camilleri Podesta, M. T., Fenech, A. G., & Grech, G. (2015). Identification of novel drug combinations to target molecular pathways involved in breast cancer. In proceedings of the AACR Special Conference: Targeting thePI3K-mTOR Network in Cancer, Philadelphia. Molecular Cancer Therapeutics, 14(7 Suppl): Abstract nr B22. |
Abstract: | Introduction: At a global level breast cancer is the second most common cancer, and the most frequent in women. Statins are 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) inhibitors. HMG-CoA reductase is a rate-limiting enzyme in the mevalonate pathway, making it important in the pathology of cancer. The serine/threonine kinase, mammalian target of rapamycin (mTOR)regulates cell survival, proliferation and growth via translational initiation control, and this pathway is deregulated in many types of cancer which are associated with phosphatidylinositol-3-kinase (PI3K)/Akt signaling activation. HMG-CoA reductase expression is dependent oneukaryotic translation initiation factor 4E (eIF4E), and requires high translation initiation efficiency for polysome recruitment. eIF4E availability is reduced by mTOR inhibitors such asrapamycin and metformin, leading to a reduction in HMG-CoA reductase expression. [Excerpt] |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/103728 |
Appears in Collections: | Scholarly Works - FacM&SPat |
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