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DC Field | Value | Language |
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dc.contributor.author | Gerada, Jurgen | - |
dc.contributor.author | Gerada, Eleanor | - |
dc.contributor.author | Grech, Gabriella | - |
dc.contributor.author | Ellul, Pierre | - |
dc.date.accessioned | 2022-11-16T16:55:50Z | - |
dc.date.available | 2022-11-16T16:55:50Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Gerada, J., Gerada, E., Abdilla, S., Grech, G., & Ellul, P. (2015). Anti-Endomysial Antibody May Predict a Second Endoscopy in Coeliac-Suspected Patients with False Negative Index Duodenal Biopsies. Austin Journal of Gastroenterology, 2(1), 1029. | en_GB |
dc.identifier.issn | 23819219 | - |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/103734 | - |
dc.description.abstract | Background/aims: A subset of coeliac-suspected patients requires 2 Oesophagogastroduodenoscopies (OGDs) to achieve histological confirmation. Their index OGD would fail to reach diagnosis despite 4 duodenal biopsies suggested by guidelines. We compared this subgroup of patients with other coeliac patients requiring 1 endoscopy and recognize any predictors to identify the former group. | en_GB |
dc.description.abstract | Methods: Coeliac-suspected patients at our department underwent an OGD. Clinical, serological and histological data were retrieved from medical notes. Group 1 comprised patients who achieved diagnosis with 1 OGD. Group 2 required 2 OGDs. | en_GB |
dc.description.abstract | Results: 178 patients underwent an OGD (mean age 47 years; 73.6% females). 12 patients (6.7%) required 2 OGDs. Both groups had the same mean number of duodenal biopsies at their index endoscopy (4.6 vs 4.5, P=0.76). In Group 2, the number of biopsies was higher at the second endoscopy (6.4 vs 4.5, P=0.028). Group 2 showed a negative or lower positivity for anti-EMA (P=0.039) and a lower anti-tTG IgA level (P=0.06) than Group 1. | en_GB |
dc.description.abstract | Conclusion: Anti-EMA seronegativity or low positivity in coeliac-suspected patients indicates the need for more duodenal biopsies to achieve diagnosis and avoiding subsequent OGDs. This finding makes anti-EMA testing crucial in coeliac diagnostics. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Austin Publishing Group | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Celiac disease -- Diagnosis | en_GB |
dc.subject | Celiac disease -- Patients -- Malta -- Case studies | en_GB |
dc.subject | Intestine, Small -- Biopsy | en_GB |
dc.title | Anti-endomysial antibody may predict a second endoscopy in coeliac-suspected patients with false negative index duodenal biopsies | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.publication.title | Austin Journal of Gastroenterology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
Files in This Item:
File | Description | Size | Format | |
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Anti endomysial antibody may predict a second endoscopy in coeliac suspected patients with false negative index duodenal biopsies 2015.pdf | 1.53 MB | Adobe PDF | View/Open |
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