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DC Field | Value | Language |
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dc.contributor.author | Cassar, Kevin | - |
dc.contributor.author | Ford, Isabel | - |
dc.contributor.author | Greaves, Mike | - |
dc.contributor.author | Bachoo, Paul | - |
dc.contributor.author | Brittenden, Julie | - |
dc.date.accessioned | 2022-11-21T06:55:50Z | - |
dc.date.available | 2022-11-21T06:55:50Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Cassar, K., Ford, I., Greaves, M., Bachoo, P., & Brittenden, J. (2005). Randomized clinical trial of the antiplatelet effects of aspirin–clopidogrel combination versus aspirin alone after lower limb angioplasty. Journal of British Surgery, 92(2), 159-165. | en_GB |
dc.identifier.issn | 13652168 | - |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/103785 | - |
dc.description.abstract | There is a high risk of reocclusion after successful lower limb angioplasty. Platelets play a central role in this process. The aim of this study was to investigate the antiplatelet effect of a combination of aspirin and clopidogrel compared with aspirin alone in patients with claudication undergoing endovascular revascularization. Methods This was a double-blind randomized placebo-controlled trial. Some 132 patients were randomized to clopidogrel and aspirin or placebo and aspirin, with a loading dose 12 h before endovascular intervention. Flow cytometric measurements of platelet fibrinogen binding and P-selectin expression were taken as measures of platelet function at baseline, 12 h after the loading dose, and 1 h, 24 h and 30 days after intervention. Results Within 12 h of the loading dose, platelet activation in the clopidogrel group had decreased (P-selectin by 27·3 per cent, P = 0·017; fibrinogen binding by 34·7 per cent, P = 0·024; stimulated fibrinogen binding by 49·2 per cent, P < 0·001). No change was observed in the placebo group. Platelet function in the clopidogrel group was significantly suppressed compared with baseline at 1 h, 24 h and 30 days after endovascular intervention (stimulated fibrinogen binding by 53·9, 51·7 and 57·2 per cent respectively; all P < 0·001). Conclusion A combination of clopidogrel and aspirin inhibited platelet function more than aspirin alone in patients with claudication before and after angioplasty. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Wiley-Blackwell Publishing Ltd. | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Clopidogrel | en_GB |
dc.subject | Blood platelet disorders | en_GB |
dc.subject | Aspirin | en_GB |
dc.subject | Intermittent claudication -- Patients | en_GB |
dc.subject | Blood platelets -- Activation | en_GB |
dc.subject | Leg -- Blood-vessels -- Diseases | en_GB |
dc.subject | Clinical trials | en_GB |
dc.title | Randomized clinical trial of the antiplatelet effects of aspirin–clopidogrel combination versus aspirin alone after lower limb angioplasty | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1002/bjs.4810 | - |
dc.publication.title | British Journal of Surgery | en_GB |
Appears in Collections: | Scholarly Works - FacM&SSur |
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Randomized_clinical_trial_of_the_antiplatelet_effects_of_aspirin–clopidogrel_combination_versus_aspirin_alone_after_lower_limb_angioplasty(2005).pdf | 449.59 kB | Adobe PDF | View/Open |
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