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DC Field | Value | Language |
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dc.contributor.author | Mizzi, Anabelle | - |
dc.contributor.author | Cassar, Kevin | - |
dc.contributor.author | Bowen, Catherine J. | - |
dc.contributor.author | Camilleri, Liberato | - |
dc.contributor.author | Formosa, Cynthia | - |
dc.date.accessioned | 2022-12-09T08:02:10Z | - |
dc.date.available | 2022-12-09T08:02:10Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Mizzi, A., Cassar, K., Bowen, C. J., Camilleri, L., & Formosa, C. (2022). The impact of diabetes in intermittent claudication : a prospective cohort study. The International Journal of Lower Extremity Wounds, 1-10. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/104258 | - |
dc.description.abstract | The aim of this study was to determine the lower-limb outcome in patients with intermittent claudication (IC) and to identify predictors for deterioration. This study employed a prospective observational cohort single-centre design. One hundred fifty patients with IC attending a vascular surgery unit for the first time were recruited. Lower limb perfusion was assessed utilising ankle brachial index (ABI) measures, toe-brachial index (TBI) measures, Doppler waveform analysis and the walking impairment questionnaire. Follow-up was conducted after 1 year and 2 years following recruitment to assess haemodynamic parameters, symptom severity and outcome. Recruited participants had a mean age of 69.7 (±9.3) years, BMI 27.8(±4.2) and 79.3% were men. Significant haemodynamic decline (decline in ABPI by ≥0.15 and/or decline in TBPI by≥0.1) occurred in 50.6% of the cohort within 2 years of whom 23.3% developed chronic limb threatening ischaemia (CLTI) with rest pain and/or tissue loss. Baseline ABPI, ABPI≤0.5, TBPI≤0.39, infrapopliteal artery (IPA) disease and high Haemoglobin A1c were identified as significant predictors for deterioration to CLI. (P<.05, binomial logistic regression). Patients with IC are at a high risk of developing CLTI within 2 years. Risk of lower limb adverse events is tripled in patients with IPA disease, low ankle and toe pressures and poorly controlled diabetes. Early identification of those at high risk for early deterioration may justify a paradigm shift in the management of this subgroup. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Sage | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Diabetes | en_GB |
dc.subject | Blood-vessels -- Diseases | en_GB |
dc.subject | Intermittent claudication | en_GB |
dc.title | The impact of diabetes in intermittent claudication : a prospective cohort study | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1177/15347346221142189 | - |
dc.publication.title | The International Journal of Lower Extremity Wounds | en_GB |
Appears in Collections: | Scholarly Works - FacHScPod Scholarly Works - FacSciSOR |
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