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https://www.um.edu.mt/library/oar/handle/123456789/104380| Title: | Translation of IGBP1 mRNA contributes to the regulation of expansion and differentiation of erythroid progenitors |
| Other Titles: | 89 Translation of IGBP1 mRNA contributes to the regulation of expansion and differentiation of erythroid progenitors |
| Authors: | Nieradka, Andrzej Grech, Godfrey Blazquez-Domingo, Montserrat Beug, Hartmut Lindern, Marieke von |
| Keywords: | Erythroid precursor cells Cell differentiation -- Molecular aspects Cell proliferation -- Molecular aspects |
| Issue Date: | 2007 |
| Publisher: | Elsevier |
| Citation: | Nieradka, A., Grech, G., Blazquez-Domingo, M., Beug, H., & von Lindern, M. (2007). Translation of IGBP1 mRNA contributes to the regulation of expansion and differentiation of erythroid progenitors. Blood Cells, Molecules and Diseases, 2(38), 162-163. |
| Abstract: | Erythroid progenitors can be expanded in vitro in the presence of erythropoietin (Epo), stem cell factor (SCF) and dexamethasone, while they differentiate to enucleated erythrocytes in presence of Epo only. Our main aims are to identify (i) signaling pathways that control expansion of erythroid progenitors and (ii) genes regulated by these signalling pathways. SCF strongly activates phosphotidylinositol 3 kinase (PI3K). Since inhibition of PI3K with LY294002 induces terminal differentiation of erythroid progenitors under Epo and SCF stimulation, SCF seems to enhance renewal divisions of erythroid progenitors via a PI3K-dependent mechanism. [Excerpt] |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/104380 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
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|---|---|---|---|---|
| Translation of IGBP1 mRNA contributes to the regulation of expansion and differentiation of erythroid progenitors 2007.pdf Restricted Access | 63.44 kB | Adobe PDF | View/Open Request a copy |
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