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https://www.um.edu.mt/library/oar/handle/123456789/104404| Title: | Hyperoxia induces defective epo-induced signal transduction and loss of expansion capacity in Fanca- and Fancg-deficient erythroid progenitors |
| Authors: | Lindern, Marieke von Akker, Emile van den Vrugt, Henri van de Grech, Godfrey Arwert, Fre Lowenberg, Bob Touw, Ivo |
| Keywords: | Fanconi's anemia -- Molecular aspects Erythropoietin -- Physiological aspects Erythroid precursor cells Hyperoxia |
| Issue Date: | 2004 |
| Publisher: | American Society of Hematology |
| Citation: | Von Lindern, M., Van den Akker, E., Van de Vrugt, H., Grech, G., Arwert, F., Lowenberg, B., & Touw, I. (2004). Hyperoxia Induces Defective Epo-Induced Signal Transduction and Loss of Expansion Capacity in Fanca-and Fancg-Deficient Erythroid Progenitors. Blood, 104(11), 2837. |
| Abstract: | Fanconi anemia (FA) is characterized by chromosomal instability and bone marrow hypoplasia. To explore the mechanism of FA-related bone marrow failure, we studied erythropoietin (Epo)-dependent proliferation and differentiation of erythroid progenitors expanded from mice lacking the Fanca or Fancg gene. Erythroid progenitors can be expanded in serum-free medium supplemented with Epo, Stem Cell Factor (SCF) and glucocorticoids. [Excerpt] |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/104404 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
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|---|---|---|---|---|
| Hyperoxia induces defective epo induced signal transduction and loss of expansion capacity in Fanca and Fancg deficient erythroid progenitors 2004.pdf Restricted Access | 68.99 kB | Adobe PDF | View/Open Request a copy |
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