Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/108528
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dc.contributor.authorCaruana, Andrea-
dc.contributor.authorSavona-Ventura, Charles-
dc.contributor.authorCalleja-Agius, Jean-
dc.date.accessioned2023-04-14T10:04:53Z-
dc.date.available2023-04-14T10:04:53Z-
dc.date.issued2023-
dc.identifier.citationCaruan, A., Savona-Ventura, C. & Calleja-Agius, J. (2023). COX isozymes and non-uniform neoangiogenesis : what is their role in endometriosis? Prostaglandins & Other Lipid Mediators, 10.1016/j.prostaglandins.2023.106734en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/108528-
dc.description.abstractThis literature review compared the efficacy in of NSAIDs with a placebo in pain relief and disease regression of endometriosis. Despite the poor evidence found, the results showed that NSAIDs were more effective in pain relief with regressive effects on the endometriotic lesions compared to placebo. We postulate herein that COX-2 is chiefly responsible for pain whilst COX-1 is responsible mainly for the establishment of endometriotic lesions. Hence, there must be a temporal difference in the activation of the two isozymes. We differentiated between two pathways in the conversion of arachidonic acid to prostaglandins by the COX isozymes referred to as ‘direct’ and indirect’, supporting our initial theory. Finally, we postulate that there are two stages of neoangiogenesis in the formation of endometriotic lesions; ‘founding’ that first establishes blood supply and ‘maintenance’ that upkeeps it This is fertile ground for further research in a niche that needs more literature. Its aspects may be diversely explored. The theories we propose offer information for a more targeted treatment of endometriosis.en_GB
dc.language.isoenen_GB
dc.publisherElsevier Inc.en_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectCyclooxygenasesen_GB
dc.subjectEnzymesen_GB
dc.subjectIsoenzymesen_GB
dc.subjectEndometriosisen_GB
dc.subjectBlood-vessels -- Abnormalitiesen_GB
dc.titleCOX isozymes and non-uniform neoangiogenesis : what is their role in endometriosis?en_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1016/j.prostaglandins.2023.106734-
dc.publication.titleProstaglandins & Other Lipid Mediatorsen_GB
dc.contributor.creatorCalleja-Agius-
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