Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/108748
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dc.contributor.authorScerri, Jeanesse-
dc.contributor.authorRuoff, Felix-
dc.contributor.authorTemplin, Markus-
dc.contributor.authorGrech, Godfrey-
dc.contributor.authorScerri, Christian-
dc.date.accessioned2023-04-21T05:09:10Z-
dc.date.available2023-04-21T05:09:10Z-
dc.date.issued2020-
dc.identifier.citationScerri, J., Ruoff, F., Templin, M., Grech, G., & Scerri, C. (2020). Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling. Cancer Research, 80(16_Supplement), 1915-1915.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/108748-
dc.description.abstractIntroduction: The widespread clinical use of monoclonal antibodies such as trastuzumab in personalized medicine, targeting upstream proteins such as receptors with cascading effects on downstream signaling, elicits the importance of studying the phosphoproteome in the investigation of resistance to targeted therapy. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in expression and activity of proteins in key signal transduction pathways, in cellular models of resistance.en_GB
dc.language.isoenen_GB
dc.publisherAmerican Association for Cancer Researchen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectBreast -- Cancer -- Chemotherapyen_GB
dc.subjectMonoclonal antibodiesen_GB
dc.subjectTrastuzumaben_GB
dc.subjectHER-2 proteinen_GB
dc.subjectCancer -- Gene therapyen_GB
dc.titleIntrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profilingen_GB
dc.title.alternativeAbstract 1915 : intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profilingen_GB
dc.typeconferenceObjecten_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.bibliographicCitation.conferencenameAnnual Meeting of the American Association for Cancer Research 2020en_GB
dc.bibliographicCitation.conferenceplacePhiladelphia, United States. 27-28/04/2020 & 22-24/06/2020.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1158/1538-7445.AM2020-1915-
dc.publication.titleCancer Researchen_GB
Appears in Collections:Scholarly Works - FacM&SPat



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