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DC Field | Value | Language |
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dc.contributor.author | Scerri, Jeanesse | - |
dc.contributor.author | Ruoff, Felix | - |
dc.contributor.author | Templin, Markus | - |
dc.contributor.author | Grech, Godfrey | - |
dc.contributor.author | Scerri, Christian | - |
dc.date.accessioned | 2023-04-21T05:09:10Z | - |
dc.date.available | 2023-04-21T05:09:10Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Scerri, J., Ruoff, F., Templin, M., Grech, G., & Scerri, C. (2020). Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling. Cancer Research, 80(16_Supplement), 1915-1915. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/108748 | - |
dc.description.abstract | Introduction: The widespread clinical use of monoclonal antibodies such as trastuzumab in personalized medicine, targeting upstream proteins such as receptors with cascading effects on downstream signaling, elicits the importance of studying the phosphoproteome in the investigation of resistance to targeted therapy. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in expression and activity of proteins in key signal transduction pathways, in cellular models of resistance. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | American Association for Cancer Research | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Breast -- Cancer -- Chemotherapy | en_GB |
dc.subject | Monoclonal antibodies | en_GB |
dc.subject | Trastuzumab | en_GB |
dc.subject | HER-2 protein | en_GB |
dc.subject | Cancer -- Gene therapy | en_GB |
dc.title | Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling | en_GB |
dc.title.alternative | Abstract 1915 : intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling | en_GB |
dc.type | conferenceObject | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.bibliographicCitation.conferencename | Annual Meeting of the American Association for Cancer Research 2020 | en_GB |
dc.bibliographicCitation.conferenceplace | Philadelphia, United States. 27-28/04/2020 & 22-24/06/2020. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1158/1538-7445.AM2020-1915 | - |
dc.publication.title | Cancer Research | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPat |
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Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest phospho protein profiling 2020.pdf Restricted Access | 147.05 kB | Adobe PDF | View/Open Request a copy |
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