Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/108806| Title: | Multiscale genomic, transcriptomic and proteomic analysis of colorectal cancer cell lines to identify novel biomarkers |
| Authors: | Briffa, Romina Grech, Godfrey Um, Inhwa Faratian, Dana Zhou, Ying Langdon, Simon P. Harrison, David J. |
| Keywords: | Colon (Anatomy) -- Cancer -- Treatment Proteomics -- Methodology Biochemical markers -- Diagnostic use Gene expression -- Molecular aspects |
| Issue Date: | 2015 |
| Publisher: | University of Malta. Medical School |
| Citation: | Briffa, R., Grech, G., Um, I., Faratian, D., Zhou, Y., Langdon, S.P., & Harrison, D. J. (2015). Multiscale genomic, transcriptomic and proteomic analysis of colorectal cancer cell lines to identify novel biomarkers. IX Malta Medical School Conference abstract book, OP1.38. |
| Abstract: | Introduction: Resistance to colorectal cancer (CRC) therapies is a significant cause of treatment failure. We used an in vitro model to identify novel therapeutic targets, explain mechanisms of carcinogenesis and resistance to therapy, and ultimately aid patient stratification for therapy. Methods: A panel of 15 CRC cell lines was profiled by comparative genomic hybridisation, gene expression profiling, reverse phase protein array analysis, and chemosensitivity assays with respect to 5fluorouracil, oxaliplatin, and BEZ235. As proof of concept, fluorescence in situ hybridization and automated quantitative protein analysis were employed to investigate a candidate biomarker in a CRC patient cohort (n=n8). |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/108806 |
| ISSN: | 18133339 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Multiscale genomic transcriptomic and proteomic analysis of colorectal cancer cell lines to identify novel biomarkers 2015.pdf | 91.44 kB | Adobe PDF | View/Open |
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