Expression of protein phosphatase 2 (PP2A) inhibitory subunits in breast cancer cell lines

Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/108811

Title:	Expression of protein phosphatase 2 (PP2A) inhibitory subunits in breast cancer cell lines
Authors:	Grixti, Maria Pia Saliba, Christian Baldacchino, Shawn Scerri, Christian Grech, Godfrey
Keywords:	Phosphoprotein phosphatases Breast -- Cancer -- Treatment -- Case studies Cancer -- Molecular aspects RNA -- Analysis
Issue Date:	2015
Publisher:	University of Malta. Medical School
Citation:	Grixti, M.P., Saliba, C., Baldacchino, S., Scerri, C., & Grech, G. (2015). Expression of protein phosphatase 2 (PP2A) inhibitory subunits in breast cancer cell lines. IX Malta Medical School Conference abstract book, P4.11.
Abstract:	Introduction: PP2A plays an integral role in the regulation of a number of major signalling pathways involved in the maintenance of normal cell division and survival. PP2A endogenous inhibitory subunits, namely SET, CIP2A and IGBP1, commonly found overexpressed in cancer, can suppress this PP2A activity resulting in cell proliferation and survival. In this study we investigated the expression of PP2A inhibitory subunits in breast cancer cell lines and overexpressed SET, CIP2A and IGBP1 in selected breast cancer cell lines.
URI:	https://www.um.edu.mt/library/oar/handle/123456789/108811
ISSN:	18133339
Appears in Collections:	Scholarly Works - FacM&SPat

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