Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/108812| Title: | Mutational analysis of c-KIT and PDGFRA in GIST cases diagnosed locally |
| Authors: | Busuttil, Charlene Masini, Maria Saliba, Christian Falzon, Sharon Grech, Godfrey Degaetano, James |
| Keywords: | Proto-oncogene proteins c-kit Platelet-derived growth factor Gastrointestinal stromal tumors -- Diagnosis -- Malta CD antigens |
| Issue Date: | 2015 |
| Publisher: | University of Malta. Medical School |
| Citation: | Busuttil, C., Masini, M., Saliba, C., Falzon, S., Grech, G., & Degaetano, J. (2015). Mutational analysis of c-KIT and PDGFRA in GIST cases diagnosed locally. IX Malta Medical School Conference abstract book, OP1.39. |
| Abstract: | Introduction: The pathogenesis of most gastrointestinal stromal tumours (GISTs) is associated with activating mutations of the proto-oncogene tyrosine kinase KIT (c-KIT). Activating mutations are also found in the homologous tyrosine kinase platelet-derived growth factor receptor a (PDGFRA). Accurate diagnosis of GIST is essential due to the availability of targeted therapy. Immunohistochemistry (IHC) for CD117 (c-KIT receptor) is routinely performed in the diagnostic workup, however, it does not provide complete sensitivity, as there are nearly 5% of GISTs that are CD117 negative. The aim of this study was to identify cKIT and PDGFRA mutations present in GIST cases diagnosed locally. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/108812 |
| ISSN: | 18133339 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Mutational analysis of c KIT and PDGFRA in GIST cases diagnosed locally 2015.pdf | 127.73 kB | Adobe PDF | View/Open |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.