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https://www.um.edu.mt/library/oar/handle/123456789/108813| Title: | Amiloride induces alternative splicing of the PP2Acα mRNA in haematopoietic cell lines |
| Authors: | Gauci, Stephanie Saliba, Christian Baldacchino, Shawn Fenech, Anthony Grech, Godfrey |
| Keywords: | Chronic myeloid leukemia -- Treatment Amiloride -- Therapeutic use Messenger RNA Alternative splicing |
| Issue Date: | 2015 |
| Publisher: | University of Malta. Medical School |
| Citation: | Gauci, S., Saliba, C., Baldacchino, S., Fenech, A., & Grech, G. (2015). Disease-free Survival in Amiloride induces alternative splicing of the PP2Acα mRNA in haematopoietic cell lines. IX Malta Medical School Conference abstract book, OP4.36. |
| Abstract: | Introduction: Targeting BCRABL1 by imatinib has proven successful for the treatment of Chronic Myeloid Leukemia (CML) patients. Nonetheless, a cumulative 5year failure rate of 17% still exists due to therapeutic resistance. Increased expression of BCRABL1 inhibits PP2A activity, promoting survival and proliferation. Previous studies established that an isoform of the catalytic subunit a of PP2A (PP2Aca) is predominant in 15% of CML. This study investigates alternate splicing of PP2Aca as a novel potential mechanism of therapeutic resistance in CML. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/108813 |
| ISSN: | 18133339 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Amiloride induces alternative splicing of the PP2Aca mRNA in haematopoietic cell lines 2015.pdf | 82.88 kB | Adobe PDF | View/Open |
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