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DC Field | Value | Language |
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dc.contributor.author | Pierucci, Massimo | - |
dc.contributor.author | Pitruzzella, Alessandro | - |
dc.contributor.author | Valentino, Mario | - |
dc.contributor.author | Zammit, Christian | - |
dc.contributor.author | Muscat, Richard | - |
dc.contributor.author | Benigno, Arcangelo | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.date.accessioned | 2015-02-02T15:47:43Z | - |
dc.date.available | 2015-02-02T15:47:43Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Malta Medical Journal. 2011, Vol.23(3), p. 32-37 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/1091 | - |
dc.description.abstract | Compelling evidence has shown a pivotal role of dopaminergic function in drug addiction. Recently, the Habenula (Hb) has attracted a great deal of attention as another target for nicotine in the brain because of its role in regulating dopamine (DA), gamma-aminobutyric acid (GABA) and serotonin (5-HT) systems. Nicotine acts binding to acetylcholine receptors that are widely distributed in the brain. Interestingly, the receptor subtypes that mediate nicotine withdrawal responses are highly expressed in the Hb. Moreover, the block of habenular nicotinic receptors in animals chronically treated with nicotine enhances withdrawal responses once nicotine is discontinued. Furthermore, it has been shown how a high dose of nicotine can cause massive degeneration almost exclusively in the medial habenula (MHb) and its output tract, the fasciculus retroflexus. Thus, symptoms associated with nicotine withdrawal may be caused by dysfunctions of the Hb output. Therefore, Hb might be of fundamental importance in the expression of nicotine reinforcing properties and withdrawal. Here, we will focus on the role of the lateral habenula (LHb) on nicotine modulation of DA function and we will evaluate LHb interaction with the rostromedial tegmental nucleus (RMTg), a GABAergic area, and the serotonergic raphé nuclei. Furthermore, as LHb has high density expression of 5-HT2C receptors, these subtypes might be important in the control of its neuronal activity and output to the midbrain monoaminergic and GABAergic systems. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Malta Medical Journal | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Nicotine -- Physiological effect | en_GB |
dc.subject | Drug addiction -- Dopamine | en_GB |
dc.subject | GABA -- Receptors | en_GB |
dc.subject | Electrophysiology | en_GB |
dc.subject | Brain -- Drug effects | - |
dc.title | Lateral Habenula contribution in Nicotine addiction : focus on Dopamine, GABA and Serotonin Interactions | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | - |
Appears in Collections: | MMJ, Volume 23, Issue 3 MMJ, Volume 23, Issue 3 Scholarly Works - FacM&SAna Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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2011.Vol23.Issue3.A6.pdf | Lateral Habenula Contribution in Nicotine Addiction: focus on Dopamine, GABA and Serotonin Interactions | 161.7 kB | Adobe PDF | View/Open |
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