Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/109580
Title: The role of FBXW7 in gynecologic malignancies
Authors: Di Fiore, Riccardo
Suleiman, Sherif
Drago-Ferrante, Rosa
Subbannayya, Yashwanth
Suleiman, Sarah
Vasileva-Slaveva, Mariela
Yordanov, Angel
Pentimalli, Francesca
Giordano, Antonio
Calleja-Agius, Jean
Keywords: F-Box-WD repeat-containing protein 7
Tumor suppressor proteins
Generative organs, Female -- Cancer -- Diagnosis
Generative organs, Female -- Cancer -- Treatment
MicroRNA -- Health aspects
Issue Date: 2023
Publisher: MDPI
Citation: Di Fiore, R., Suleiman, S., Drago-Ferrante, R., Subbannayya, Y., Suleiman, S., Vasileva-Slaveva, M.,…Calleja-Agius, J. (2023). The Role of FBXW7 in Gynecologic Malignancies. Cells, 12, 1415. Doi: 10.3390/cells12101415
Abstract: The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7, hCDC4, SEL10 or hAGO, is encoded by the gene FBXW7. It is a crucial component of the Skp1-Cullin1-F-box (SCF) complex, which is a ubiquitin ligase. This complex aids in the degradation of many oncoproteins, such as cyclin E, c-JUN, c-MYC, NOTCH, and MCL1, via the ubiquitin-proteasome system (UPS). The FBXW7 gene is commonly mutated or deleted in numerous types of cancer, including gynecologic cancers (GCs). Such FBXW7 mutations are linked to a poor prognosis due to increased treatment resistance. Hence, detection of the FBXW7 mutation may possibly be an appropriate diagnostic and prognostic biomarker that plays a central role in determining suitable individualized management. Recent studies also suggest that, under specific circumstances, FBXW7 may act as an oncogene. There is mounting evidence indicating that the aberrant expression of FBXW7 is involved in the development of GCs. The aim of this review is to give an update on the role of FBXW7 as a potential biomarker and also as a therapeutic target for novel treatments, particularly in the management of GCs.
URI: https://www.um.edu.mt/library/oar/handle/123456789/109580
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