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DC Field | Value | Language |
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dc.contributor.author | Spiteri, Lorie-Emm | - |
dc.date.accessioned | 2023-05-19T17:27:01Z | - |
dc.date.available | 2023-05-19T17:27:01Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Spiteri, L.-E. (2023). Interleukin-1 and inflammation in cardiovascular disease. Minima Medica, 31-38. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/109641 | - |
dc.description.abstract | Interleukin 1 (IL-1) is a pro-inflammatory cytokine with important roles in innate immunity and tissue homeostasis. Inflammation is crucial as it protects the host by reacting against pathogens and repairing tissues however, improper use of the inflammatory cascade results in pathogenesis of several acute and chronic diseases. IL-1 together with the NLR family pyrin domain containing 3 (NLRP3) inflammasome are key players in inflammation and modulate cardiac function as well. Literature concerning the role of IL-1 and the inflammasome is reviewed, together with a concise narrative overview pathways affected during signaling. Specific examples of the role of IL-1 in pathogenic outcomes in cardiovascular disease (CVD) are also reviewed. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | MMSA | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Interleukin-1 | en_GB |
dc.subject | Cardiovascular Diseases | en_GB |
dc.subject | Inflammation | en_GB |
dc.subject | Atherosclerosis | en_GB |
dc.subject | Myocardial infarction | en_GB |
dc.title | Interleukin-1 and inflammation in cardiovascular disease | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
Appears in Collections: | Minima Medica 2023 Minima Medica 2023 |
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File | Description | Size | Format | |
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Interleukin_1_and_inflammation_in_cardiovascular_disease_2023.pdf | 503.22 kB | Adobe PDF | View/Open |
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