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DC Field | Value | Language |
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dc.contributor.author | Saliba, Luke | - |
dc.contributor.author | Sammut, Keith | - |
dc.contributor.author | Tonna, Christabelle | - |
dc.contributor.author | Pavli, Foteini | - |
dc.contributor.author | Valdramidis, Vasilis | - |
dc.contributor.author | Gatt, Ray | - |
dc.contributor.author | Giordmaina, Ryan | - |
dc.contributor.author | Camilleri, Liberato | - |
dc.contributor.author | Atanasio, William | - |
dc.contributor.author | Buhagiar, Joseph P. | - |
dc.contributor.author | Schembri Wismayer, Pierre | - |
dc.date.accessioned | 2023-05-23T13:55:49Z | - |
dc.date.available | 2023-05-23T13:55:49Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Saliba, L., Sammut, K., Tonna, C., Pavli, F., Valdramidis, V., Gatt, R.,...Schembri Wismayer, P. (2023). FeMn and FeMnag Biodegradable Alloys: An In Vitro And In Vivo Investigation. Heliyon 9. https://doi.org/10.1016/j.heliyon.2023.e15671. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/109862 | - |
dc.description.abstract | Iron-based biodegradable metal bone graft substitutes are in their infancy but promise to fill bone defects that arise after incidents such as trauma and revision arthroplasty surgery. Before clinical use however, a better understanding of their in vivo biodegradability, potential cytotoxicity and biocompatibility is required. In addition, these implants must ideally be able to resist infection, a complication of any implant surgery. In this study there was significant in vitro cytotoxicity caused by pure Fe, FeMn, FeMn1Ag and FeMn5Ag on both human foetal osteoblast (hFOB) and mouse pre-osteoblast (MC3T3-E1) cell lines. In vivo experiments on the other hand showed no signs of ill-effect on GAERS rats with the implanted FeMn, FeMn1Ag and FeMn5Ag pins being removed largely uncorroded. All Fe-alloys showed anti-bacterial performance but most markedly so in the Ag-containing alloys, there is significant bacterial resistance in vitro. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier Ltd | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Biodegradable products | en_GB |
dc.subject | Cell mediated cytotoxicity | en_GB |
dc.subject | Biocompatible Materials | en_GB |
dc.subject | Drug resistance in microorganisms | en_GB |
dc.title | FeMn and FeMnAg biodegradable alloys : an in vitro and in vivo investigation | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.heliyon.2023.e15671 | - |
dc.publication.title | Heliyon | en_GB |
Appears in Collections: | Scholarly Works - FacSciSOR |
Files in This Item:
File | Description | Size | Format | |
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FeMn_and_FeMnAg_biodegradable_alloys.pdf | 15.65 MB | Adobe PDF | View/Open |
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