Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/115488
Title: | Mismatch repair protein expression defects in endometrioid endometrial adenocarcinoma |
Authors: | Brincat, Mark Buhagiar, Tiffany Falzon, Sharon Ariff, Sabrina Bugeja, Simona Debono, James Mark Muscat Baron, Yves Calleja, Neville |
Keywords: | Endometrium -- Cancer -- Malta Adenocarcinoma -- Malta Immunohistochemistry Women patients -- Malta |
Issue Date: | 2020 |
Publisher: | John Wiley & Sons, Inc. |
Citation: | Brincat, M., Buhagiar, T., Falzon, S., Ariff, S., Bugeja, S., Debono, J. M.,...Calleja, N. (2020). Mismatch repair protein expression defects in endometrioid endometrial adenocarcinoma. International Journal of Gynecologic Cancer, 30:A121-A122. |
Abstract: | Introduction/Background Endometrial cancer has been shown to be the sentinel cancer in over half the female patients with heritable mismatch repair (MMR) mutations as part of Lynch syndrome. Immunohistochemical testing for MMR protein expression in endometrial cancer is the first screening test identifying cases that potentially harbour familial cancer syndrome-related mutations. MMR has also become a biomarker to predict response to targeted therapeutics such as in immune-checkpoint blockade. This is the first study to describe the prevalence of MMR protein expression defects in Maltese endometrial carcinoma patients and the correlation with patient age at diagnosis. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/115488 |
Appears in Collections: | Scholarly Works - FacM&SPH |
Files in This Item:
File | Description | Size | Format | |
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Mismatch_repair_protein_expression_defects_in_endometrioid_endometrial_adenocarcinoma_2020.pdf Restricted Access | 2.18 MB | Adobe PDF | View/Open Request a copy |
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