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DC Field | Value | Language |
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dc.contributor.author | Nakaya, Tadashi | - |
dc.contributor.author | Alexiou, Panagiotis | - |
dc.contributor.author | Maragkakis, Manolis | - |
dc.contributor.author | Chang, Alexandra | - |
dc.contributor.author | Mourelatos, Zissimos | - |
dc.date.accessioned | 2024-01-23T15:04:05Z | - |
dc.date.available | 2024-01-23T15:04:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Nakaya, T., Alexiou, P., Maragkakis, M., Chang, A., & Mourelatos, Z. (2013). FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns. Rna, 19(4), 498-509. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/117781 | - |
dc.description.abstract | Dominant mutations and mislocalization or aggregation of Fused in Sarcoma (FUS), an RNA-binding protein (RBP), cause neuronal degeneration in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), two incurable neurological diseases. However, the function of FUS in neurons is not well understood. To uncover the impact of FUS in the neuronal transcriptome, we used high-throughput sequencing of immunoprecipitated and cross-linked RNA (HITS–CLIP) of FUS in human brains and mouse neurons differentiated from embryonic stem cells, coupled with RNA-seq and FUS knockdowns. We report conserved neuronal RNA targets and networks that are regulated by FUS. We find that FUS regulates splicing of genes coding for RBPs by binding to their highly conserved introns. Our findings have important implications for understanding the impact of FUS in neurodegenerative diseases and suggest that perturbations of FUS can impact the neuronal transcriptome via perturbations of RBP transcripts. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Cold Spring Harbor Lab | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | RNA-protein interactions | en_GB |
dc.subject | Deep learning (Machine learning) | en_GB |
dc.subject | Transfer learning (Machine learning) | en_GB |
dc.title | FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1261/rna.037804.112. | - |
dc.publication.title | Rna | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
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