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DC Field | Value | Language |
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dc.contributor.author | Ibrahim, Fadia | - |
dc.contributor.author | Maragkakis, Manolis | - |
dc.contributor.author | Alexiou, Panagiotis | - |
dc.contributor.author | Maronski, Margaret A. | - |
dc.contributor.author | Dichter, Marc A. | - |
dc.contributor.author | Mourelatos, Zissimos | - |
dc.date.accessioned | 2024-01-23T15:09:50Z | - |
dc.date.available | 2024-01-23T15:09:50Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Ibrahim, F., Maragkakis, M., Alexiou, P., Maronski, M. A., Dichter, M. A., & Mourelatos, Z. (2013). Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome. Cell reports, 3(2), 301-308. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/117782 | - |
dc.description.abstract | RNA binding proteins (RBPs) have emerged as major causative agents of amyotrophic lateral sclerosis (ALS). To investigate the function of TAF15, an RBP recently implicated in ALS, we explored its target RNA repertoire in normal human brain and mouse neurons. Coupling high-throughput sequencing of immunoprecipitated and crosslinked RNA with RNA sequencing and TAF15 knockdowns, we identified conserved TAF15 RNA targets and assessed the impact of TAF15 on the neuronal transcriptome. We describe a role of TAF15 in the regulation of splicing for a set of neuronal RNAs encoding proteins with essential roles in synaptic activities. We find that TAF15 is required for a critical alternative splicing event of the zeta-1 subunit of the glutamate N-methyl-D-aspartate receptor (Grin1) that controls the activity and trafficking of NR1. Our study uncovers neuronal RNA networks impacted by TAF15 and sets the stage for investigating the role of TAF15 in ALS pathogenesis. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | RNA-protein interactions | en_GB |
dc.subject | Deep learning (Machine learning) | en_GB |
dc.subject | Transfer learning (Machine learning) | en_GB |
dc.title | Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.celrep.2013.01.021 | - |
dc.publication.title | Cell reports | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
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