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https://www.um.edu.mt/library/oar/handle/123456789/118928| Title: | A review of the current evidence on gadolinium deposition in the brain |
| Authors: | Pullicino, Richard Radon, Mark Biswas, Shubhabrata Bhojak, Maneesh Das, Kumar |
| Keywords: | Dentate nucleus Pharmacokinetics Magnetic resonance imaging Drug Monitoring Gadolinium -- Toxicology Brain -- Effect of drugs on |
| Issue Date: | 2018 |
| Publisher: | Springer Medizin |
| Citation: | Pullicino, R., Radon, M., Biswas, S., Bhojak, M., & Das, K. (2018). A review of the current evidence on gadolinium deposition in the brain. Clinical Neuroradiology, 28(2), 159-169. |
| Abstract: | Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/118928 |
| ISSN: | 18691439 |
| Appears in Collections: | Scholarly Works - FacM&SCRNM |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| A_Review_of_the_Current_Evidence_on_Gadolinium_Deposition_in_the_Brain(2018).pdf Restricted Access | 403.33 kB | Adobe PDF | View/Open Request a copy |
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