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Title: | ECCO guidelines on extraintestinal manifestations in inflammatory bowel disease |
Authors: | Gordon, Hannah Burisch, Johan Ellul, Pierre Karmiris, Konstantinos Katsanos, Konstantinos Allocca, Mariangela Bamias, Giorgos Barreiro-de Acosta, Manuel Braithwaite, Tasanee Greuter, Thomas Harwood, Catherine Juillerat, Pascal Lobaton, Triana Müller-Ladner, Ulf Noor, Nurulamin Pellino, Gianluca Savarino, Edoardo Schramm, Christoph Soriano, Alessandra Stein, Jürgen Michael Uzzan, Mathieu van Rheenen, Patrick F. Vavricka, Stephan R. Vecchi, Maurizio Zuily, Stephane Kucharzik, Torsten |
Keywords: | Inflammatory bowel diseases Intestinal mucosa Anemia Crohn's disease |
Issue Date: | 2024 |
Publisher: | Oxford University Press |
Citation: | Gordon, H., Burisch, J., Ellul, P., Karmiris, K., Katsanos, K., Allocca, M., ... & Kucharzik, T. (2024). ECCO guidelines on extraintestinal manifestations in inflammatory bowel disease. Journal of Crohn's and Colitis, 18(1), 1-37. |
Abstract: | This is the second European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on extraintestinal manifestations [EIMs] of inflammatory bowel disease [IBD] and anaemia. Up to 50% of patients with IBD will develop at least one EIM, which may impact each body system ; hence they are a source of considerable morbidity, or even mortality in the case of primary sclerosing cholangitis [PSC] or venous thromboembolic events [VTE]. Broadly, EIMs can be categorized as classical, arising from inflammatory pathology at distant sites, the consequences of systemic inflammation and treatment, or wider associations. The underlying pathophysiology of extraintestinal inflammation is not fully understood. Potential driving forces include extension of the immune-mediated response from the inflamed gut to other organs, with shifts in leukocyte trafficking, changes to the intestinal microbiota, and underlying predisposing genetic factors. The systemic consequences of IBD lead to broader associations, including VTEs and anaemia. Whether these are strictly EIMs is of debate, but they are included within this guideline as they incur a considerable health burden to patients with IBD. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/120085 |
Appears in Collections: | Scholarly Works - FacM&SMed |
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ECCO_guidelines_on_extraintestinal_manifestations_in_inflammatory_bowel_disease_2024.pdf Restricted Access | 884.22 kB | Adobe PDF | View/Open Request a copy |
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