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DC Field | Value | Language |
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dc.contributor.author | Khoury, Elie | - |
dc.contributor.author | Acquaviva, Eric | - |
dc.contributor.author | Purper-Ouakil, Diane | - |
dc.contributor.author | Delorme, Richard | - |
dc.contributor.author | Ellul, Pierre | - |
dc.date.accessioned | 2024-03-21T15:12:49Z | - |
dc.date.available | 2024-03-21T15:12:49Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Khoury, E., Acquaviva, E., Purper-Ouakil, D., Delorme, R., & Ellul, P. (2023). Meta-analysis of personal and familial co-occurrence of Attention Deficit/Hyperactivity Disorder and Bipolar Disorder. Neuroscience & Biobehavioral Reviews, 146, 105050. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/120121 | - |
dc.description.abstract | Background: Attention Deficit Disorder / Hyperactivity (ADHD) and Bipolar Disorder (BD) are highly comorbid disorders. Studies have raised the hypothesis of shared genetic, neurobiological, and clinical factors. This would entail an excess risk of co-occurrence of both disorders. Objective: We present the first meta-analysis of individual and familial associations between ADHD and BD. Methods: From 2688 references, 59 were included, with a total of 550,379 ADHD patients, 57,799 BD patients and 12,608,137 controls. Results: Personal history of ADHD increased the risk of BD (OR = 6.06), and conversely individuals with BD had an increased risk of ADHD (OR = 8.94). First-degree relatives of ADHD patients had an increased risk of BD (OR = 1.94). Offspring of individuals with BD had a higher risk for ADHD (OR = 2.33). Finally, first-degree relatives of BD patients had an increased risk of ADHD (OR = 2.71). Conclusion: We show a clear epidemiological overlap between ADHD and BD, as well as a strong familial association which advocates in favor of a more systematic screening. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier Ltd | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Attention-deficit hyperactivity disorder | en_GB |
dc.subject | Bipolar disorder | en_GB |
dc.subject | Meta-analysis | en_GB |
dc.subject | Medicine -- Research -- Evaluation | en_GB |
dc.subject | Comorbidity | en_GB |
dc.title | Meta-analysis of personal and familial co-occurrence of attention deficit/hyperactivity disorder and bipolar disorder | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.neubiorev.2023.105050 | - |
dc.publication.title | Neuroscience & Biobehavioral Reviews | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
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Meta_analysis_of_personal_and_familial_co_occurrence_of_attention_deficithyperactivity_disorder_and_bipolar_disorder_2023.pdf Restricted Access | 4.53 MB | Adobe PDF | View/Open Request a copy |
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