Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/120214
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dc.contributor.authorVale Rodrigues, Rita-
dc.contributor.authorSladek, Margaret-
dc.contributor.authorKatsanos, Konstantinos-
dc.contributor.authorvan der Woude, C. Janneke-
dc.contributor.authorWei, Juan-
dc.contributor.authorVavricka, Stephan R.-
dc.contributor.authorTeich, Niels-
dc.contributor.authorEllul, Pierre-
dc.contributor.authorSavarino, Edoardo-
dc.contributor.authorChaparro, Maria-
dc.contributor.authorBeaton, David-
dc.contributor.authorOliveira, Ana Maria-
dc.contributor.authorFragaki, Maria-
dc.contributor.authorBar-Gil Shitrit, Ariella-
dc.contributor.authorRamos, Laura-
dc.contributor.authorKarmiris, Konstantinos-
dc.date.accessioned2024-03-22T13:11:33Z-
dc.date.available2024-03-22T13:11:33Z-
dc.date.issued2020-
dc.identifier.citationVale Rodrigues, R., Sladek, M., Katsanos, K., van der Woude, C. J., Wei, J., Vavricka, S. R.,...ECCO CONFER investigators. (2020). Diagnosis and outcome of oesophageal Crohn’s disease. Journal of Crohn's and Colitis, 14(5), 624-629.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/120214-
dc.description.abstractBackground and Aims: Crohn’s disease [CD] can involve any part of the gastrointestinal tract. We aimed to characterize the clinical, endoscopic and histological features and treatment outcomes of CD patients with oesophageal involvement. Methods: We collected cases through a retrospective multicentre European Crohn’s and Colitis Organisation CONFER [COllaborative Network For Exceptionally Rare case reports] project. Clinical data were recorded in a standardized case report form. Results: A total of 40 patients were reported (22 males, mean [±SD, range] age at oesophageal CD diagnosis: 25 [±13.3, 10–71] years and mean time of follow-up: 67 [±68.1, 3–240] months). Oesophageal involvement was established at CD diagnosis in 26 patients [65%] and during follow-up in 14. CD was exclusively located in the oesophagus in two patients. Thirteen patients [32.2%] were asymptomatic at oesophageal disease diagnosis. Oesophageal strictures were present in five patients and fistulizing oesophageal disease in one. Eight patients exhibited granulomas on biopsies. Proton-pump inhibitors [PPIs] were administered in 37 patients [92.5%]. Three patients underwent endoscopic dilatation for symptomatic strictures but none underwent oesophageal-related surgery. Diagnosis in pre-established CD resulted in treatment modifications in 9/14 patients. Clinical remission of oesophageal disease was seen in 33/40 patients [82.5%] after a mean time of 7 [±5.6, 1–18] months. Follow-up endoscopy was performed in 29/40 patients and 26/29 [89.7%] achieved mucosal healing. Conclusion: In this case series the endoscopic and histological characteristics of isolated oesophageal CD were similar to those reported in other sites of involvement. Treatment was primarily conservative, with PPIs administered in the majority of patients and modifications in pre-existing inflammatory bowel disease-related therapy occurring in two-thirds of them. Clinical and endoscopic remission was achieved in more than 80% of the patients.en_GB
dc.language.isoenen_GB
dc.publisherOxford University Pressen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectEuropean Crohn's and Colitis Organisationen_GB
dc.subjectInflammatory bowel diseasesen_GB
dc.subjectCrohn's diseaseen_GB
dc.subjectUlcerative colitisen_GB
dc.subjectEsophagusen_GB
dc.titleDiagnosis and outcome of oesophageal Crohn’s diseaseen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.contributor.corpauthorECCO CONFER investigatorsen_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1093/ecco-jcc/jjz201-
dc.publication.titleJournal of Crohn's and Colitisen_GB
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