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Title: | Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) |
Authors: | Vallejo-Vaz, Antonio J. De Marco, Martina Stevens, Christophe A.T. Akram, Asif Freiberger, Tomas Kees Hovingh, G. Kastelein, John J.P. Mata, Pedro Raal, Frederick J. Santos, Raul D. Soran, Handrean Watts, Gerald F. Abifadel, Marianne Aguilar-Salinas, Carlos A. Al-Khnifsawi, Mutaz AlKindi, Fahad A. Alnouri, Fahad Alonso, Rodrigo Al-Rasadi, Khalid Al-Sarraf, Ahmad Ashavaid, Tester F. Binder, Christoph J. Bogsrud, Martin P. Bourbon, Mafalda Bruckert, Eric Chlebus, Krzysztof Corral, Pablo Descamps, Olivier Durst, Ronen Ezhov, Marat Fras, Zlatko Genest, Jacques Groselj, Urh Harada-Shiba, Mariko Kayikcioglu, Meral Lalic, Katarina Lam, Carolyn S.P. Latkovskis, Gustavs Laufs, Ulrich Liberopoulos, Evangelos Lin, Jie Maher, Vincent Majano, Nelson David Marais, A. März, Winfried Mirrakhimov, Erkin Miserez, André R. Mitchenko, Olena Nawawi, Hapizah M. Nordestgaard, Børge G. Paragh, György Petrulioniene, Zaneta Pojskic, Belma Postadzhiyan, Arman Reda, Ashraf Reiner, Željko Sadoh, Wilson E. Sahebkar, Amirhossein Shehab, Abdullah Shek, Aleksander B. Stoll, Mario Su, Ta-Chen Subramaniam, Tavintharan Susekov, Andrey V. Symeonides, Phivos Tilney, Myra Kay Tomlinson, Brian Truong, Thanh-Huong Tselepis, Alexandros D. Tybjærg-Hansen, Anne Vázquez-Cárdenas, Alejandra Viigimaa, Margus Vohnout, Branislav Widén, Elisabeth Yamashita, Shizuya Banach, Maciej Gaita, Dan Jiang, Lixin Nilsson, Lennart Santos, Lourdes E. Schunkert, Heribert Tokgözoğlu, Lale Car, Josip Catapano, Alberico L. Ray, Kausik K. |
Authors: | EAS Familial Hypercholesterolaemia Studies Collaboration European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration |
Keywords: | Hypophosphatemia, Familial Cardiovascular system -- Diseases -- Diagnosis Phosphates -- Metabolism Calcium -- Metabolism |
Issue Date: | 2018 |
Publisher: | Elsevier |
Citation: | Vallejo-Vaz, A. J., De Marco, M., Stevens, C. A., Akram, A., Freiberger, T., Hovingh, G. K., ... & EAS Familial Hypercholesterolaemia Studies Collaboration. (2018). Overview of the current status of familial hypercholesterolaemia care in over 60 countries-The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Atherosclerosis, 277, 234-255. |
Abstract: | Background and aims: Management of familial hypercholesterolaemia (FH) may vary across different settings due to factors related to population characteristics, practice, resources and/or policies. We conducted a survey among the worldwide network of EAS FHSC Lead Investigators to provide an overview of FH status in different countries. Methods: Lead Investigators from countries formally involved in the EAS FHSC by mid-May 2018 were invited to provide a brief report on FH status in their countries, including available information, programmes, initiatives, and management. Results: 63 countries provided reports. Data on FH prevalence are lacking in most countries. Where available, data tend to align with recent estimates, suggesting a higher frequency than that traditionally considered. Low rates of FH detection are reported across all regions. National registries and education programmes to improve FH awareness/knowledge are a recognised priority, but funding is often lacking. In most countries, diagnosis primarily relies on the Dutch Lipid Clinics Network criteria. Although available in many countries, genetic testing is not widely implemented (frequent cost issues). There are only a few national official government programmes for FH. Under-treatment is an issue. FH therapy is not universally reimbursed. PCSK9-inhibitors are available in ∼2/3 countries. Lipoprotein-apheresis is offered in ∼60% countries, although access is limited. Conclusions: FH is a recognised public health concern. Management varies widely across countries, with overall suboptimal identification and under-treatment. Efforts and initiatives to improve FH knowledge and management are underway, including development of national registries, but support, particularly from health authorities, and better funding are greatly needed. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/120360 |
Appears in Collections: | Scholarly Works - FacM&SMed |
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