Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/120360
Title: Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
Authors: Vallejo-Vaz, Antonio J.
De Marco, Martina
Stevens, Christophe A.T.
Akram, Asif
Freiberger, Tomas
Kees Hovingh, G.
Kastelein, John J.P.
Mata, Pedro
Raal, Frederick J.
Santos, Raul D.
Soran, Handrean
Watts, Gerald F.
Abifadel, Marianne
Aguilar-Salinas, Carlos A.
Al-Khnifsawi, Mutaz
AlKindi, Fahad A.
Alnouri, Fahad
Alonso, Rodrigo
Al-Rasadi, Khalid
Al-Sarraf, Ahmad
Ashavaid, Tester F.
Binder, Christoph J.
Bogsrud, Martin P.
Bourbon, Mafalda
Bruckert, Eric
Chlebus, Krzysztof
Corral, Pablo
Descamps, Olivier
Durst, Ronen
Ezhov, Marat
Fras, Zlatko
Genest, Jacques
Groselj, Urh
Harada-Shiba, Mariko
Kayikcioglu, Meral
Lalic, Katarina
Lam, Carolyn S.P.
Latkovskis, Gustavs
Laufs, Ulrich
Liberopoulos, Evangelos
Lin, Jie
Maher, Vincent
Majano, Nelson
David Marais, A.
März, Winfried
Mirrakhimov, Erkin
Miserez, André R.
Mitchenko, Olena
Nawawi, Hapizah M.
Nordestgaard, Børge G.
Paragh, György
Petrulioniene, Zaneta
Pojskic, Belma
Postadzhiyan, Arman
Reda, Ashraf
Reiner, Željko
Sadoh, Wilson E.
Sahebkar, Amirhossein
Shehab, Abdullah
Shek, Aleksander B.
Stoll, Mario
Su, Ta-Chen
Subramaniam, Tavintharan
Susekov, Andrey V.
Symeonides, Phivos
Tilney, Myra Kay
Tomlinson, Brian
Truong, Thanh-Huong
Tselepis, Alexandros D.
Tybjærg-Hansen, Anne
Vázquez-Cárdenas, Alejandra
Viigimaa, Margus
Vohnout, Branislav
Widén, Elisabeth
Yamashita, Shizuya
Banach, Maciej
Gaita, Dan
Jiang, Lixin
Nilsson, Lennart
Santos, Lourdes E.
Schunkert, Heribert
Tokgözoğlu, Lale
Car, Josip
Catapano, Alberico L.
Ray, Kausik K.
Authors: EAS Familial Hypercholesterolaemia Studies Collaboration
European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration
Keywords: Hypophosphatemia, Familial
Cardiovascular system -- Diseases -- Diagnosis
Phosphates -- Metabolism
Calcium -- Metabolism
Issue Date: 2018
Publisher: Elsevier
Citation: Vallejo-Vaz, A. J., De Marco, M., Stevens, C. A., Akram, A., Freiberger, T., Hovingh, G. K., ... & EAS Familial Hypercholesterolaemia Studies Collaboration. (2018). Overview of the current status of familial hypercholesterolaemia care in over 60 countries-The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Atherosclerosis, 277, 234-255.
Abstract: Background and aims: Management of familial hypercholesterolaemia (FH) may vary across different settings due to factors related to population characteristics, practice, resources and/or policies. We conducted a survey among the worldwide network of EAS FHSC Lead Investigators to provide an overview of FH status in different countries. Methods: Lead Investigators from countries formally involved in the EAS FHSC by mid-May 2018 were invited to provide a brief report on FH status in their countries, including available information, programmes, initiatives, and management. Results: 63 countries provided reports. Data on FH prevalence are lacking in most countries. Where available, data tend to align with recent estimates, suggesting a higher frequency than that traditionally considered. Low rates of FH detection are reported across all regions. National registries and education programmes to improve FH awareness/knowledge are a recognised priority, but funding is often lacking. In most countries, diagnosis primarily relies on the Dutch Lipid Clinics Network criteria. Although available in many countries, genetic testing is not widely implemented (frequent cost issues). There are only a few national official government programmes for FH. Under-treatment is an issue. FH therapy is not universally reimbursed. PCSK9-inhibitors are available in ∼2/3 countries. Lipoprotein-apheresis is offered in ∼60% countries, although access is limited. Conclusions: FH is a recognised public health concern. Management varies widely across countries, with overall suboptimal identification and under-treatment. Efforts and initiatives to improve FH knowledge and management are underway, including development of national registries, but support, particularly from health authorities, and better funding are greatly needed.
URI: https://www.um.edu.mt/library/oar/handle/123456789/120360
Appears in Collections:Scholarly Works - FacM&SMed

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