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DC Field | Value | Language |
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dc.contributor.author | Ellul, Pierre | - |
dc.contributor.author | Schembri, John | - |
dc.contributor.author | Vella Baldacchino, Andrea | - |
dc.contributor.author | Molnár, Tamas | - |
dc.contributor.author | Resal, Tamas | - |
dc.contributor.author | Allocca, Mariangela | - |
dc.contributor.author | Furfaro, Federica | - |
dc.contributor.author | Dal Buono, Arianna | - |
dc.contributor.author | Theodoropoulou, Angeliki | - |
dc.contributor.author | Fragaki, Maria | - |
dc.contributor.author | Tsoukali, Emmanouela | - |
dc.contributor.author | Mantzaris, Gerassimos J. | - |
dc.contributor.author | Phillips, Frank M. | - |
dc.contributor.author | Radford, Shellie | - |
dc.contributor.author | Moran, Gordon | - |
dc.contributor.author | Gonzalez, Haidee | - |
dc.contributor.author | Sebastian, Shaji | - |
dc.contributor.author | Fousekis, Fotios | - |
dc.contributor.author | Christodoulou, Dimitrios | - |
dc.contributor.author | Snir, Ifat | - |
dc.contributor.author | Lerner, Zlata | - |
dc.contributor.author | Yanai, Henit | - |
dc.contributor.author | Michalopoulos, Georgios | - |
dc.contributor.author | Tua, Julia | - |
dc.contributor.author | Camilleri, Liberato | - |
dc.contributor.author | Papamichael, Kostas | - |
dc.contributor.author | Karmiris, Konstantinos | - |
dc.contributor.author | Katsanos, Konstantinos | - |
dc.date.accessioned | 2024-04-01T13:20:42Z | - |
dc.date.available | 2024-04-01T13:20:42Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Ellul, P., Schembri, J., Vella Baldacchino, A., Molnár, T., Resal, T., Allocca, M., ... & Katsanos, K. (2023). Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease. Journal of Crohn's and Colitis, 17(4), 489-496. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/120416 | - |
dc.description.abstract | Background and Aims: Post-inflammatory polyps [PIPs] are considered as indicators of previous episodes of severe inflammation and mucosal ulceration. Inflammatory bowel disease [IBD], namely Crohn’s disease [CD] and ulcerative colitis [UC], exhibit a perpetuating, relapsing and remitting pattern, and PIPs are a frequent sequela of chronicity. The aim of this study was to determine whether a high PIP burden is associated with a more severe disease course in patients with IBD. Methods: This was a multinational, multicentre, retrospective study. IBD patients previously diagnosed with PIPs were retrieved from the endoscopic database of each centre. PIP burden was evaluated and associated with demographic and clinical data as well as factors indicating a more unfavourable disease course. Results: A total of 504 IBD patients with PIPs were recruited [male: 61.9%]. The mean age at IBD diagnosis was 36.9 [±16.8] years. Most patients [74.8%] were diagnosed with UC. A high PIP burden was present in 53.4% of patients. On multivariable Cox regression analysis, a high PIP burden was independently associated with treatment escalation (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.04–1.75; p = 0.024), hospitalization [HR 1.90; 95% CI 1.24–2.90; p = 0.003], need for surgery [HR 2.28; 95% CI 1.17–4.44, p = 0.02] and younger age at diagnosis [HR 0.99, 95% CI 0.98–0.99; p = 0.003]. Conclusion: PIP burden was associated with a more severe outcome. Future prospective studies should focus on the characterization of PIP burden as to further risk stratify this patient cohort. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Oxford University Press | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Inflammatory bowel diseases | en_GB |
dc.subject | Crohn's disease | en_GB |
dc.subject | Ulcerative colitis | en_GB |
dc.subject | Intestinal polyps | en_GB |
dc.subject | Intestines -- Tumors | en_GB |
dc.subject | Colon (Anatomy) -- Cancer | en_GB |
dc.title | Post-inflammatory polyp burden as a prognostic marker of disease-outcome in patients with inflammatory bowel disease | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1093/ecco-jcc/jjac169 | - |
dc.publication.title | Journal of Crohn's and Colitis | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
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Post_inflammatory_polyp_burden_as_a_prognostic_marker_of_disease_outcome_in_patients_with_inflammatory_bowel_disease_2023.pdf | 780.08 kB | Adobe PDF | View/Open |
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