Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/120632
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dc.contributor.authorFogleman, Nicholas D.-
dc.contributor.authorApers, Silke-
dc.contributor.authorMoons, Philip-
dc.contributor.authorMorrison, Stacey-
dc.contributor.authorWittekind, Samuel G.-
dc.contributor.authorTomlin, Martha-
dc.contributor.authorGosney, Kathy-
dc.contributor.authorSluman, Maayke A.-
dc.contributor.authorJohansson, Bengt-
dc.contributor.authorEnomoto, Junko-
dc.contributor.authorDellborg, Mikael-
dc.contributor.authorLu, Chun-Wei-
dc.contributor.authorSubramanyan, Raghavan-
dc.contributor.authorLuyckx, Koen-
dc.contributor.authorBudts, Werner-
dc.contributor.authorJackson, Jamie-
dc.contributor.authorKovacs, Adrienne-
dc.contributor.authorSoufi, Alexandra-
dc.contributor.authorEriksen, Katrine-
dc.contributor.authorThomet, Corina-
dc.contributor.authorBerghammer, Malin-
dc.contributor.authorCallus, Edward-
dc.contributor.authorFernandes, Susan M.-
dc.contributor.authorCaruana, Maryanne-
dc.contributor.authorCook, Stephen C.-
dc.contributor.authorMackie, Andrew S.-
dc.contributor.authorWhite, Kamila S.-
dc.contributor.authorKutty, Shelby-
dc.contributor.authorVeldtman, Gruschen-
dc.contributor.authorGrech, Victor E.-
dc.contributor.authorVella, Sheena-
dc.contributor.authorMifsud, Anabel-
dc.contributor.authorBorg, Neville-
dc.contributor.authorChircop, Daniel-
dc.contributor.authorMercieca Balbi, Matthew-
dc.contributor.authorVella Critien, Rachel-
dc.contributor.authorFarrugia, James-
dc.contributor.authorGatt, Yanika-
dc.contributor.authorMuscat, Darlene-
dc.date.accessioned2024-04-10T06:11:47Z-
dc.date.available2024-04-10T06:11:47Z-
dc.date.issued2017-
dc.identifier.citationFogleman, N. D., Apers, S., Moons, P., Morrison, S., Wittekind, S. G., Tomlin, M.,...Veldtman, G. (2017). Regional variation in quality of life in patients with a Fontan circulation: a multinational perspective. American Heart Journal, 193, 55-62.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/120632-
dc.description.abstractBackground: Impaired quality of life (QOL) is associated with congenital heart disease (CHD) and country of residence; however, few studies have compared QOL in patients with differing complexities of CHD across regional populations. The current study examined regional variation in QOL outcomes in a large multinational sample of patients with a Fontan relative to patients with atrial septal defects (ASDs) and ventricular septal defects (VSDs).en_GB
dc.description.abstractMethods: From the Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease—International Study (APPROACH-IS), 405 patients (163 Fontan and 242 ASD/VSD) across Asia, Europe, and North America provided consent for access to their medical records and completed a survey evaluating QOL (0 to 100 linear analog scale). Primary CHD diagnosis, disease complexity, surgical history, and documented history of mood and anxiety disorders were recorded. Differences in QOL, medical complications, and mood and anxiety disorders between Fontan and ASD/VSD patients, and across geographic regions, were examined using analysis of covariance. Hierarchical regression analyses were conducted to identify variables associated with the QOL ratings.en_GB
dc.description.abstractResults: Patients with a Fontan reported significantly lower QOL, and greater medical complications and mood and anxiety disorders relative to patients with ASD/VSD. Inpatient cardiac admissions, mood disorders, and anxiety disorders were associated with lower QOL among patients with a Fontan, and mood disorders were associated with lower QOL among patients with ASD/VSD. Regional differences for QOL were not observed in patients with a Fontan; however, significant differences were identified in patients with ASD/VSD.en_GB
dc.description.abstractConclusions: Regional variation of QOL is commonplace in adults with CHD; however, it appears affected by greater disease burden. Among patients with a Fontan, regional variation of QOL is lost. Specific attempts to screen for QOL and mood and anxiety disorders among CHD patients may improve the care of patients with the greatest disease burden.en_GB
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectCongenital heart disease -- Patientsen_GB
dc.subjectFontan procedureen_GB
dc.subjectAtrial septal defectsen_GB
dc.subjectVentricular septal defectsen_GB
dc.subjectQuality of life -- Health aspectsen_GB
dc.titleRegional variation in quality of life in patients with a Fontan circulation : a multinational perspectiveen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.contributor.corpauthorAPPROACH-IS Consortiumen_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1016/j.ahj.2017.07.019-
dc.publication.titleAmerican Heart Journalen_GB
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