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DC Field | Value | Language |
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dc.contributor.author | Bosica, Giovanna | - |
dc.contributor.author | Abdilla, Roderick | - |
dc.date.accessioned | 2024-04-22T06:36:16Z | - |
dc.date.available | 2024-04-22T06:36:16Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Bosica, G., & Abdilla, R. (2024). Novel biopolymer-based catalyst for the multicomponent synthesis of 𝑁-aryl-4-aryl-substituted dihydropyridines derived from simple and complex anilines. Molecules, 29, 1884. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/121113 | - |
dc.description.abstract | Although Hantzsch synthesis has been an established multicomponent reaction method for more than a decade, its derivative, whereby an aniline replaces ammonium acetate as the nitrogen source, has not been explored at great length. Recent studies have shown that the products of such a reaction, N-aryl-4-aryldihydropyridines (DHPs), have significant anticancer activity. In this study, we successfully managed to synthesize a wide range of DHPs (18 examples, 8 of which were novel) using a metal-free, mild, inexpensive, recoverable, and biopolymer-based heterogeneous catalyst, known as piperazine, which was supported in agar–agar gel. In addition, 8 further examples (3 novel) of such dihydropyridines were synthesized using isatin instead of aldehyde as a reactant, producing spiro-linked structures. Lastly, this catalyst managed to afford an unprecedented product that was derived using an innovative technique—a combination of multicomponent reactions. Essentially, the product of our previously reported aza-Friedel–Crafts multicomponent reaction could itself be used as a reactant instead of aniline in the synthesis of more complex dihydropyridines. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | MDPI AG | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Biopolymers -- Synthesis | en_GB |
dc.subject | Dihydropyridines -- Synthesis | en_GB |
dc.subject | Heterogeneous catalysis | en_GB |
dc.subject | Peptides -- Analysis | en_GB |
dc.subject | Green chemistry | en_GB |
dc.title | Novel biopolymer-based catalyst for the multicomponent synthesis of 𝑁-aryl-4-aryl-substituted dihydropyridines derived from simple and complex anilines | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3390/molecules29081884 | - |
dc.publication.title | Molecules | en_GB |
Appears in Collections: | Scholarly Works - FacSciChe |
Files in This Item:
File | Description | Size | Format | |
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Novel biopolymer based catalyst for the multicomponent synthesis of N aryl 4 arylsubstituted dihydropyridines derived from simple and complex anilines 2024.pdf | 5.65 MB | Adobe PDF | View/Open |
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