Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/121393
Title: To boldly go where no microRNAs have gone before : spaceflight impact on risk for small-for-gestational-age infants
Authors: Corti, Giada
Kim, JangKeun
Enguita, Francisco
Guarnieri, Joseph
Grossman, Lawrence
Costes, Sylvain
Fuentealba, Matias
Scott, Ryan
Magrini, Andrea
Sanders, Lauren
Furman, David
Calleja-Agius, Jean
Mason, Christopher E.
Galeano, Diego
Bottini, Massimo
Beheshti, Afshin
Keywords: Outer space -- Exploration
Space environment
Space medicine
Life support systems (Space environment)
Pregnancy
Issue Date: 2024
Publisher: Research Square
Citation: Corti, G., Kim, J.K., Enguita, F., Guarnieri, J., Grossman, L., Costes, S.,… Beheshti, A. (2024). To boldly go where no microRNAs have gone before : spaceflight impact on risk for small-for-gestational-age infants. Nature Portfolio, 10.21203/rs.3.rs-4003363/v1
Abstract: In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses. To address this, we identify a shared microRNA (miRNA) signature between SGA and the space environment, conserved across humans and mice. These miRNAs target genes and pathways relevant to diseases and development. Employing a machine learning approach, we identify potential FDA-approved drugs to mitigate these risks, including estrogen and progesterone receptor antagonists, vitamin D receptor antagonists, and DNA polymerase inhibitors. This study underscores potential pregnancy-related health risks for female astronauts and proposes pharmaceutical interventions to counteract the impact of space travel on female health.
URI: https://www.um.edu.mt/library/oar/handle/123456789/121393
ISBN: 10.21203/rs.3.rs-4003363/v1
Appears in Collections:Scholarly Works - FacM&SAna



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