Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/123787
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dc.contributor.authorRiva, Nicoletta-
dc.contributor.authorMuscat-Baron, Lorna-
dc.contributor.authorVassallo, Carine-
dc.contributor.authorAgeno, Walter-
dc.contributor.authorRottenstreich, Amihai-
dc.contributor.authorSauvé, Nadine-
dc.contributor.authorWysokinski, Waldemar E.-
dc.contributor.authorGoldberg, Gary L.-
dc.contributor.authorSalomon, Ophira-
dc.contributor.authorLabropoulos, Nicos-
dc.contributor.authorFoulon, Arthur-
dc.contributor.authorAlSheef, Mohammed-
dc.contributor.authorGatt, Alex-
dc.contributor.authorCalleja-Agius, Jean-
dc.date.accessioned2024-06-20T07:28:59Z-
dc.date.available2024-06-20T07:28:59Z-
dc.date.issued2024-
dc.identifier.citationRiva, N., Muscat-Baron, L., Vassallo, C., Ageno, W., Rottenstreich, A., Sauvé, N.,…Calleja-Agius, J. (2024). Safety and efficacy of anticoagulant treatment in patients with ovarian vein thrombosis : a systematic review and meta-analysis of observational studies. Research and Practice in Thrombosis and Haemostasis,en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/123787-
dc.description.abstractBackground: The role of anticoagulation in ovarian vein thrombosis (OVT) is uncertain. We aimed to evaluate safety and efficacy of anticoagulant treatment in OVT patients.en_GB
dc.description.abstractMethods: A systematic search was conducted in MEDLINE, EMBASE, CENTRAL databases, up to April 2024. Eligible studies included randomized controlled trials and observational studies enrolling at least 10 adult patients with objectively diagnosed OVT and treated with any anticoagulants. The protocol was prospectively registered in PROSPERO (CRD42021270883).en_GB
dc.description.abstractResults: We included 17 observational studies (621 anticoagulated, 376 non-anticoagulated OVT patients); 9 studies enrolled mainly pregnancy/puerperium-related OVT. Most patients received heparins alone (45.7%) or proceeded to vitamin K antagonists (39.2%). The average treatment duration was ≤ 3 months in 8 studies (47.1%), > 3 to ≤ 6 months in 6 studies (35.3%), > 6 months in 3 studies (17.6%). In treated patients, mortality rate was 2.43% (95%CI, 0.54-5.41%; I2=53.8%; 12/406 patients; 13 studies); major bleeding 1.27% (95%CI, 0.48-2.38%; I2=2.5%; 7/583 patients; 15 studies); recurrent venous thromboembolism (VTE) 3.49% (95%CI, 1.12-6.95%; I2=63.5%; 22/482 patients; 15 studies); vessel recanalization 89.4% (95%CI, 74.6-98.6%; I2=80.6%; 163/184 patients; 8 studies). The rate of recurrent VTE in untreated patients was 8.65% (95%CI, 2.61-17.35); however, the difference with treated patients was not statistically significant (risk ratio 0.70; 95%CI, 0.36-1.37). At subgroup analyses, the rates of major bleeding and recurrent VTE were 0.80% (95%CI, 0.0-2.17%) and 3.81% (95%CI, 0.42-9.63%) in pregnancy/puerperium-related OVT; 1.12% (95%CI, 0.32-2.34%) and 1.78% (95%CI, 0.62-3.46%) when analysing only full-text studies.en_GB
dc.description.abstractConclusions: There is paucity of literature regarding OVT. Our results suggest that anticoagulation is associated with low rates of major bleeding and recurrent VTE.en_GB
dc.language.isoenen_GB
dc.publisherWiley-Blackwell Publishing Ltd.en_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectBlood -- Coagulationen_GB
dc.subjectAnticoagulants (Medicine)en_GB
dc.subjectMedicine -- Research -- Evaluationen_GB
dc.subjectMeta-analysisen_GB
dc.subjectThrombophlebitisen_GB
dc.subjectSystematic reviews (Medical research)en_GB
dc.titleSafety and efficacy of anticoagulant treatment in patients with ovarian vein thrombosis : a systematic review and meta-analysis of observational studiesen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.publication.titleResearch and Practice in Thrombosis and Haemostasisen_GB
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