Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/127909
Title: Changes in the landscape of anticoagulation : a focus on the direct oral anticoagulants.
Authors: Ageno, Walter
Caramelli, Bruno
Donadini, Marco Paolo
Girardi, Laura
Riva, Nicoletta
Keywords: Blood -- Coagulation
Thrombophlebitis
Anticoagulants (Medicine)
Issue Date: 2024
Publisher: The Lancet Publishing Group
Citation: Ageno, W., Caramelli, B., Donadini, M. P., Girardi, L. & Riva, N. (2024). Changes in the landscape of anticoagulation : a focus on the direct oral anticoagulants. Lancet Haematology, 10.1016/S2352-3026(24)00281-3
Abstract: Over the last decade, the advent of direct oral anticoagulants (DOACs) has rapidly changed the landscape of anticoagulation. In the early 2010s, DOACs became widely available for stroke prevention in atrial fibrillation and the treatment of venous thromboembolism. About 10 years later, approximately two-thirds of patients requiring oral anticoagulant treatment were receiving a DOAC. The results of several post-marketing studies consistently confirmed the findings of phase 3 clinical trials, and research has focused on new areas of development, with heterogeneous results. A role for DOACs has emerged for patients with peripheral artery disease and other challenging conditions, such as cancer-associated thrombosis, unusual-site venous thromboembolism, and end-stage renal disease. Conversely, clinical trials showed that DOACs were not efficacious in patients with valvular atrial fibrillation, mechanical heart valves, embolic strokes of undetermined source, or antiphospholipid syndrome. In this Review, we discuss the impact of DOACs in clinical practice over the last decade, new areas under development, and practical issues in the management of these drugs.
URI: https://www.sciencedirect.com/science/article/pii/S2352302624002813
https://www.um.edu.mt/library/oar/handle/123456789/127909
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