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Title: | Spatiotemporal expression and control of haemoglobin in space |
Authors: | Borg, Josef Loy, Conor Kim, JangKeun Buhagiar, Alfred Chin, Christopher Damle, Namita De Vlaminck, Iwijn Felice, Alex Liu, Tammy Matei, Irina Meydan, Cem Muratani, Masafumi Mzava, Omary Overbey, Eliah Ryon, Krista A. Smith, Scott M. Tierney, Braden T. Trudel, Guy Zwart, Sara R. Beheshti, Afshin Mason, Christopher E. Borg, Joseph J. |
Keywords: | Gene expression -- Environmental aspects Space biology -- Research Hemoglobinopathy -- Environmental aspects Human beings -- Effect of space environment on Space environment -- Research |
Issue Date: | 2024 |
Publisher: | Nature Publishing Group |
Citation: | Borg, J., Loy, C., Kim, J., Buhagiar, A., Chin, C., Damle, N.,...Borg, J. (2024). Spatiotemporal expression and control of haemoglobin in space. Nature Communications, 15(1), 4927. |
Abstract: | It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production. Haemoglobin biology provides an intriguing model for studying space omics, as it has been extensively explored at multiple -omic levels, spanning DNA, RNA, and protein analyses, in both experimental and clinical contexts. In this study, we examined the developmental expression of haemoglobin over time and space using a unique suite of multi-omic datasets available on NASA GeneLab, from the NASA Twins Study, the JAXA CFE study, and the Inspiration4 mission. Our findings reveal significant variations in globin gene expression corresponding to the distinct spatiotemporal characteristics of the collected samples. This study sheds light on the dynamic nature of globin gene regulation in response to the space environment and provides valuable insights into the broader implications of space omics research. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/130315 |
Appears in Collections: | Scholarly Works - FacHScABS |
Files in This Item:
File | Description | Size | Format | |
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Spatiotemporal expression and control of haemoglobin in space 2024.pdf | 3.45 MB | Adobe PDF | View/Open |
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