Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/130315
Title: Spatiotemporal expression and control of haemoglobin in space
Authors: Borg, Josef
Loy, Conor
Kim, JangKeun
Buhagiar, Alfred
Chin, Christopher
Damle, Namita
De Vlaminck, Iwijn
Felice, Alex
Liu, Tammy
Matei, Irina
Meydan, Cem
Muratani, Masafumi
Mzava, Omary
Overbey, Eliah
Ryon, Krista A.
Smith, Scott M.
Tierney, Braden T.
Trudel, Guy
Zwart, Sara R.
Beheshti, Afshin
Mason, Christopher E.
Borg, Joseph J.
Keywords: Gene expression -- Environmental aspects
Space biology -- Research
Hemoglobinopathy -- Environmental aspects
Human beings -- Effect of space environment on
Space environment -- Research
Issue Date: 2024
Publisher: Nature Publishing Group
Citation: Borg, J., Loy, C., Kim, J., Buhagiar, A., Chin, C., Damle, N.,...Borg, J. (2024). Spatiotemporal expression and control of haemoglobin in space. Nature Communications, 15(1), 4927.
Abstract: It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production. Haemoglobin biology provides an intriguing model for studying space omics, as it has been extensively explored at multiple -omic levels, spanning DNA, RNA, and protein analyses, in both experimental and clinical contexts. In this study, we examined the developmental expression of haemoglobin over time and space using a unique suite of multi-omic datasets available on NASA GeneLab, from the NASA Twins Study, the JAXA CFE study, and the Inspiration4 mission. Our findings reveal significant variations in globin gene expression corresponding to the distinct spatiotemporal characteristics of the collected samples. This study sheds light on the dynamic nature of globin gene regulation in response to the space environment and provides valuable insights into the broader implications of space omics research.
URI: https://www.um.edu.mt/library/oar/handle/123456789/130315
Appears in Collections:Scholarly Works - FacHScABS

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