Editorial : biomolecular modifications in endocrine-related cancers, volume II

Abstract

Following the successful publication of the first volume on modifications in biomolecules (proteins, RNAs, and DNAs) (https://www.frontiersin.org/research-topics/24966/biomolecular-modifications-in-endocrine-related-cancers) and the rapid progress in this field, we have edited a second volume to further highlight the importance and complexity of biomolecular (proteins, RNAs, and DNAs) modifications in the cancer biological system. First, we focused on genomics, transcriptomics, proteomics, and bioinformatics, which enable in-depth research on large-scale biomolecular modifications, including the determination of modification sites and abundances in DNAs, RNAs, and proteins, modification-mediated signaling pathways and functions, and antagonistic and synergistic effects between modifications in a biomolecule. Second, we focused on in DNAs, RNAs, and proteins, which are very important factors in causing the diversity of a biomolecule, ultimately resulting in proteoforms that are comprehensively determined by the amino acid sequence, post-translational modifications (PTMs), spatial conformation, cofactors, binding partners, location, and a function (excerpt).