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https://www.um.edu.mt/library/oar/handle/123456789/131931| Title: | BCG induced lupus vulgaris : an unexpected adverse event |
| Authors: | Pace Spadaro, Elaine Xuereb Dingli, John Doffinger, Rainer Dinakantha, Kumararatne Betts, Alexandra Pace, David |
| Keywords: | BCG vaccines -- Complications -- Case studies Mycobacterium tuberculosis Skin -- Tuberculosis -- Diagnosis Lupus |
| Issue Date: | 2018 |
| Publisher: | BMJ Group |
| Citation: | Pace Spadaro, E., Xuereb Dingli, J., Doffinger, R., Dinakantha, K., Betts, A., & Pace, D. (2018). BCG induced lupus vulgaris: an unexpected adverse event. Archives of Disease in Childhood, 103(1), 71-72. |
| Abstract: | A 12-year-old boy presented with a slowly enlarging plaque, at the site of BCG vaccination (Statens Serum Institute, Danish strain 1331), administered 14 months previously. Mantoux testing showed a 14 mm induration and his interferon-gamma (IFN-γ) release assay was negative. Skin biopsy revealed non-caseating dermal granulomata composed of epithelioid histiocytes and Langhans-type multinucleated giant cells. No acid fast bacilli were seen. PCR for Mycobacterium tuberculosis complex (includes M bovis) was negative. Based on a clinical diagnosis of BCG lupus vulgaris, he was treated empirically with isoniazid, rifampicin and ethambutol for 6 months. Investigation of IFN-γ and interleukin-12 (IL-12) axis showed a reduced IFN-γ response to phytohaemagglutinin stimulation, diminished IL-12 and suboptimal down-regulation of IL-10 to IFN-γ, possibly compatible with a partial IFN-γ receptor deficiency. Mutational analysis of the IFNGR1 and IFNGR2 genes was unrevealing. The lesion healed with extensive scarring. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/131931 |
| Appears in Collections: | Scholarly Works - FacM&SPae |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| BCG induced lupus vulgaris an unexpected adverse event 2018.pdf Restricted Access | 1.53 MB | Adobe PDF | View/Open Request a copy |
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