Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/13928
Title: | Abnormalities of hemoglobin A₂ |
Authors: | Vella, Francis |
Keywords: | Hemoglobin Thalassemia Genetic disorders |
Issue Date: | 1969 |
Publisher: | The St. Luke`s Hospital Gazette |
Citation: | Vella, F. (1969). Abnormalities of hemoglobin A₂. The St. Luke`s Hospital Gazette, 4(2), 118-124. |
Abstract: | Hereditary abnormalities of the A. fraction of human hemoglobin may be: (a) structural, in which a genetically determined change in the amino acid composition and sequence of either the alpha or the delta polypetide chains, results in the production of a hemoglobin A variant and (b) quantitative, in which changes in concentration in the hemoglobin A₂ fraction occur as a result of activation or repression of the genes for either the alpha or the delta chains or as a result of the replacement of the normal genes for either of these chains by structurally mutant genes. Because the beta and delta chains of human hemoglobins are linked, a number of conditions also involving the beta chain genes (delta-beta hybrid chain hemoglobins, hereditary persistence of fetal hemoglobin, the beta thalassemias) produce changes in hemoglobin A₂ concentration. Several non-hereditary states have been shown to produce quantitative changes in the hemoglobin A₂ fraction. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/13928 |
Appears in Collections: | TSLHG, Volume 4, Issue 2 TSLHG, Volume 4, Issue 2 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Abnormalities in Haemoglobin A2.pdf | Published for the Consultant Staff Committee, St. Luke`s Hospital, Malta and the Medical and Dental Surgery Faculties of the Royal University of Malta. | 510.16 kB | Adobe PDF | View/Open |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.